Cyclometalated Platinum(II) Complexes as Highly Sensitive Luminescent Switch-On Probes for Practical Application in Protein Staining and Cell Imaging

Peng Wu, Ella Lai-Ming Wong, Dik-Lung Ma, Glenna So-Ming Tong, Kwan-Ming Ng, Chi-Ming Che*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

133 Citations (Scopus)

Abstract

Protein-staining platinum: The luminescent switch-on characteristic of the platinum(II) complex can be utilized for staining a series of proteins in sodium dodecyl sulfate-polyarcylamide gels, to give emissive gel images directly under UV light (see figure). The detection sensitivity for BSA protein is down to 6.0 ng, revealing potential practical applications of luminescent platinum(II) complexes in the luminescent signaling of biomolecules.
Original languageEnglish
Pages (from-to)3652-3656
Number of pages5
JournalChemistry - A European Journal
Volume15
Issue number15
DOIs
Publication statusPublished - 6 Apr 2009

Scopus Subject Areas

  • Catalysis
  • Organic Chemistry

User-Defined Keywords

  • Cell imaging
  • Gels
  • Luminescence
  • Noncovalent interactions
  • Platinum
  • Protein staining

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