Cyclometalated gold(iii) complexes with N-heterocyclic carbene ligands as topoisomerase i poisons

Jessie Jing Yan; Andy Lok Fung Chow; Chung Hang Leung; Raymond Wai Yin Sun; Edmond Dik Lung MA; Chi Ming Che

doi:10.1039/c001216e

Cyclometalated gold(iii) complexes with N-heterocyclic carbene ligands as topoisomerase i poisons

Jessie Jing Yan
, Andy Lok Fung Chow
, Chung Hang Leung
, Raymond Wai Yin Sun
, Edmond Dik Lung MA
, Chi Ming Che^*

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Journal article › peer-review

166 Citations (Scopus)

Abstract

A panel of stable [Au(R-CNC)(N-heterocyclic carbene)]⁺ complexes displays prominent in vitro anticancer properties; [Au(CNC)(IMe)]CF ₃SO₃ (1, IMe = 1,3-dimethylimidazol-2-ylidene) significantly poisons topoisomerase I in vitro and suppresses tumor growth in nude mice model.

Original language	English
Pages (from-to)	3893-3895
Number of pages	3
Journal	Chemical Communications
Volume	46
Issue number	22
DOIs	https://doi.org/10.1039/c001216e
Publication status	Published - 14 Jun 2010

Access to Document

10.1039/c001216e

Cite this

@article{568d13a3da5a43b2a2692fe5f8082aaa,

title = "Cyclometalated gold(iii) complexes with N-heterocyclic carbene ligands as topoisomerase i poisons",

abstract = "A panel of stable [Au(R-CNC)(N-heterocyclic carbene)]+ complexes displays prominent in vitro anticancer properties; [Au(CNC)(IMe)]CF 3SO3 (1, IMe = 1,3-dimethylimidazol-2-ylidene) significantly poisons topoisomerase I in vitro and suppresses tumor growth in nude mice model.",

author = "Yan, \{Jessie Jing\} and Chow, \{Andy Lok Fung\} and Leung, \{Chung Hang\} and Sun, \{Raymond Wai Yin\} and MA, \{Edmond Dik Lung\} and Che, \{Chi Ming\}",

note = "We acknowledge the support from the University of Hong Kong (University Development Fund) and the Area of Excellence Scheme (AoE/P-10/01) administered by the University Grants Committee (HKSAR, China).",

year = "2010",

month = jun,

day = "14",

doi = "10.1039/c001216e",

language = "English",

volume = "46",

pages = "3893--3895",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

number = "22",

}

TY - JOUR

T1 - Cyclometalated gold(iii) complexes with N-heterocyclic carbene ligands as topoisomerase i poisons

AU - Yan, Jessie Jing

AU - Chow, Andy Lok Fung

AU - Leung, Chung Hang

AU - Sun, Raymond Wai Yin

AU - MA, Edmond Dik Lung

AU - Che, Chi Ming

N1 - We acknowledge the support from the University of Hong Kong (University Development Fund) and the Area of Excellence Scheme (AoE/P-10/01) administered by the University Grants Committee (HKSAR, China).

PY - 2010/6/14

Y1 - 2010/6/14

N2 - A panel of stable [Au(R-CNC)(N-heterocyclic carbene)]+ complexes displays prominent in vitro anticancer properties; [Au(CNC)(IMe)]CF 3SO3 (1, IMe = 1,3-dimethylimidazol-2-ylidene) significantly poisons topoisomerase I in vitro and suppresses tumor growth in nude mice model.

AB - A panel of stable [Au(R-CNC)(N-heterocyclic carbene)]+ complexes displays prominent in vitro anticancer properties; [Au(CNC)(IMe)]CF 3SO3 (1, IMe = 1,3-dimethylimidazol-2-ylidene) significantly poisons topoisomerase I in vitro and suppresses tumor growth in nude mice model.

UR - https://www.scopus.com/pages/publications/77952771593

U2 - 10.1039/c001216e

DO - 10.1039/c001216e

M3 - Journal article

C2 - 20401423

AN - SCOPUS:77952771593

SN - 1359-7345

VL - 46

SP - 3893

EP - 3895

JO - Chemical Communications

JF - Chemical Communications

IS - 22

ER -

Cyclometalated gold(iii) complexes with N-heterocyclic carbene ligands as topoisomerase i poisons

Abstract

Access to Document

Other files and links

Fingerprint

Cite this