Cyclometalated gold(iii) complexes with N-heterocyclic carbene ligands as topoisomerase i poisons

Jessie Jing Yan; Andy Lok Fung Chow; Chung Hang Leung; Raymond Wai Yin Sun; Edmond Dik Lung MA; Chi Ming Che

doi:10.1039/c001216e

Cyclometalated gold(iii) complexes with N-heterocyclic carbene ligands as topoisomerase i poisons

Jessie Jing Yan, Andy Lok Fung Chow, Chung Hang Leung, Raymond Wai Yin Sun, Edmond Dik Lung MA, Chi Ming Che^*

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Journal article › peer-review

148 Citations (Scopus)

Abstract

A panel of stable [Au(R-CNC)(N-heterocyclic carbene)]⁺ complexes displays prominent in vitro anticancer properties; [Au(CNC)(IMe)]CF ₃SO₃ (1, IMe = 1,3-dimethylimidazol-2-ylidene) significantly poisons topoisomerase I in vitro and suppresses tumor growth in nude mice model.

Original language	English
Pages (from-to)	3893-3895
Number of pages	3
Journal	Chemical Communications
Volume	46
Issue number	22
DOIs	https://doi.org/10.1039/c001216e
Publication status	Published - 14 Jun 2010

Scopus Subject Areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Chemistry(all)
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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10.1039/c001216e

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abstract = "A panel of stable [Au(R-CNC)(N-heterocyclic carbene)]+ complexes displays prominent in vitro anticancer properties; [Au(CNC)(IMe)]CF 3SO3 (1, IMe = 1,3-dimethylimidazol-2-ylidene) significantly poisons topoisomerase I in vitro and suppresses tumor growth in nude mice model.",

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AU - Yan, Jessie Jing

AU - Chow, Andy Lok Fung

AU - Leung, Chung Hang

AU - Sun, Raymond Wai Yin

AU - MA, Edmond Dik Lung

AU - Che, Chi Ming

PY - 2010/6/14

Y1 - 2010/6/14

N2 - A panel of stable [Au(R-CNC)(N-heterocyclic carbene)]+ complexes displays prominent in vitro anticancer properties; [Au(CNC)(IMe)]CF 3SO3 (1, IMe = 1,3-dimethylimidazol-2-ylidene) significantly poisons topoisomerase I in vitro and suppresses tumor growth in nude mice model.

AB - A panel of stable [Au(R-CNC)(N-heterocyclic carbene)]+ complexes displays prominent in vitro anticancer properties; [Au(CNC)(IMe)]CF 3SO3 (1, IMe = 1,3-dimethylimidazol-2-ylidene) significantly poisons topoisomerase I in vitro and suppresses tumor growth in nude mice model.

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DO - 10.1039/c001216e

M3 - Journal article

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Cyclometalated gold(iii) complexes with N-heterocyclic carbene ligands as topoisomerase i poisons

Abstract

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