Cyclometalated gold(iii) complexes with N-heterocyclic carbene ligands as topoisomerase i poisons

Jessie Jing Yan, Andy Lok Fung Chow, Chung Hang Leung, Raymond Wai Yin Sun, Edmond Dik Lung MA, Chi Ming Che*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

126 Citations (Scopus)

Abstract

A panel of stable [Au(R-CNC)(N-heterocyclic carbene)]+ complexes displays prominent in vitro anticancer properties; [Au(CNC)(IMe)]CF 3SO3 (1, IMe = 1,3-dimethylimidazol-2-ylidene) significantly poisons topoisomerase I in vitro and suppresses tumor growth in nude mice model.

Original languageEnglish
Pages (from-to)3893-3895
Number of pages3
JournalChemical Communications
Volume46
Issue number22
DOIs
Publication statusPublished - 14 Jun 2010

Scopus Subject Areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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