Cyanines as new fluorescent probes for DNA detection and two-photon excited bioimaging

Xin Jiang Feng, Po Lam Wu, Frédéric Bolze, Heidi W.C. Leung, King Fai Li, Nai Ki MAK, Daniel W J KWONG, Jean François Nicoud*, Kok Wai CHEAH, Ricky M S WONG

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

102 Citations (Scopus)

Abstract

A series of cyanine fluorophores based on fused aromatics as an electron donor for DNA sensing and two-photon bioimaging were synthesized, among which the carbazole-based biscyanine exhibits high sensitivity and efficiency as a fluorescent light-up probe for dsDNA, which shows selective binding toward the AT-rich regions. The synergetic effect of the bischromophoric skeleton gives a several-fold enhancement in a two-photon absorption cross-section as well as a 25- to 100-fold enhancement in two-photon excited fluorescence upon dsDNA binding.

Original languageEnglish
Pages (from-to)2194-2197
Number of pages4
JournalOrganic Letters
Volume12
Issue number10
DOIs
Publication statusPublished - 21 May 2010

Scopus Subject Areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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