Cyanine fluorophores for cellular protection against ROS in stimulated macrophages and two-photon ROS detection

M. S. Chan, D. Xu, L. Guo, D. Y. Tam, L. S. Liu, Y. Chen, Ricky M S WONG*, P. K. Lo

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

We report the first example of a novel two-photon active, biocompatible, and macrophage cell-membrane permeable carbazole-based cyanine fluorophore for the detection of three biologically important ROS, namely, OH, O2- and OCl- in solution. This versatile probe shows cellular protection not only in stimulated macrophages from phorbol-12-myristate-13-acetate-induced morphological changes but also lipopolysaccharide-induced cytotoxicity by quenching with the O2- and OCl- production, respectively. Such protection could be visualized by a distinct change in the fluorescence intensity of the probe.

Original languageEnglish
Pages (from-to)7307-7312
Number of pages6
JournalOrganic and Biomolecular Chemistry
Volume13
Issue number26
DOIs
Publication statusPublished - 14 Jul 2015

Scopus Subject Areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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