Current advancements in Aβ luminescent probes and inhibitors of Aβ aggregation

Edmond Dik Lung MA*, Daniel Chan Shiu-Hin, Victor Pui Yan Ma, Ka Ho Leung, Hai Jing Zhong, Chung Hang Leung

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

12 Citations (Scopus)


Alzheimer's disease (AD) is a neurodegenerative disorder that severely jeopardizes the health of aging populations all over the world. According to the amyloid cascade hypothesis, the pathological progression of AD is associated with the formation of amyloid plaques in the brain, resulting from the aggregation of amyloid-β (Aβ) peptides. Over the past few years, vast efforts have been dedicated to the development of amyloid probes and inhibitors for the diagnosis and effective treatment of AD. We review here recent advancements in luminescent probes for the detection of Aβ peptide and fibrils, and the current development of small molecule inhibitors of Aβ aggregation. We also highlight the key features in each specific example, as well as review new ideas and strategies that are crucial for researchers in this field.

Original languageEnglish
Pages (from-to)830-843
Number of pages14
JournalCurrent Alzheimer Research
Issue number7
Publication statusPublished - 2012

Scopus Subject Areas

  • Neurology
  • Clinical Neurology

User-Defined Keywords

  • Aggregation inhibitor
  • Alzheimer's disease
  • Beta-amyloid
  • Luminescent probe
  • Therapeutics agents


Dive into the research topics of 'Current advancements in Aβ luminescent probes and inhibitors of Aβ aggregation'. Together they form a unique fingerprint.

Cite this