Cu(I)-Catalyzed Enantioselective Alkynylation of Thiochromones

Ling Meng, Ka Yan Ngai, Xiaoyong Chang, Zhenyang Lin, Jun Wang*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

A highly efficient asymmetric synthesis of chiral thiochromanones is developed via Cu(I)/phosphoramidite catalyzed asymmetric alkynylation of thiochromones under mild reaction conditions. The catalyst system is tolerant of various thiochromone precursors and terminal alkynes. The established asymmetric transformation provides different enatiomeric-enriched thiochromanones with more molecular complexity and enables access to chiral thioflavanones, a subgroup of flavonoid by further functionalization.

Original languageEnglish
Pages (from-to)1155–1159
JournalOrganic Letters
Volume22
Issue number3
DOIs
Publication statusPublished - 21 Jan 2020

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