Critical review on the research of chemical structure, bioactivities, and mechanism of actions of Dendrobium officinale polysaccharide

Cheuk Hei Lai; Chu Ying Huo; Jun Xu; Quan Bin Han; Li Feng Li

doi:10.1016/j.ijbiomac.2024.130315

Critical review on the research of chemical structure, bioactivities, and mechanism of actions of Dendrobium officinale polysaccharide

Cheuk Hei Lai
, Chu Ying Huo
, Jun Xu
, Quan Bin Han
, Li Feng Li^*

^*Corresponding author for this work

Research output: Contribution to journal › Journal article › peer-review

55 Citations (Scopus)

Abstract

Dendrobium officinale (Tie-Pi-Shi-Hu) is a precious traditional Chinese medicine (TCM). The principal active components are polysaccharides (DOP), which have a high potency in therapeutic applications. However, limitations in structure analysis and underlying mechanism investigation impede its further research. This review systemically and critically summarises current understanding in both areas, and points out the influence of starch impurities and the role of gut microbiota in DOP research. As challenges faced in studying natural polysaccharide investigations are common, this review contributes to a broader understanding of polysaccharides beyond DOP.

Original language	English
Article number	130315
Number of pages	12
Journal	International Journal of Biological Macromolecules
Volume	263
Early online date	19 Feb 2024
DOIs	https://doi.org/10.1016/j.ijbiomac.2024.130315
Publication status	Published - Apr 2024

User-Defined Keywords

Bioactivity
Dendrobium officinale
Gut microbiota
Polysaccharides
Structure analysis

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10.1016/j.ijbiomac.2024.130315

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title = "Critical review on the research of chemical structure, bioactivities, and mechanism of actions of Dendrobium officinale polysaccharide",

abstract = "Dendrobium officinale (Tie-Pi-Shi-Hu) is a precious traditional Chinese medicine (TCM). The principal active components are polysaccharides (DOP), which have a high potency in therapeutic applications. However, limitations in structure analysis and underlying mechanism investigation impede its further research. This review systemically and critically summarises current understanding in both areas, and points out the influence of starch impurities and the role of gut microbiota in DOP research. As challenges faced in studying natural polysaccharide investigations are common, this review contributes to a broader understanding of polysaccharides beyond DOP.",

keywords = "Bioactivity, Dendrobium officinale, Gut microbiota, Polysaccharides, Structure analysis",

author = "Lai, \{Cheuk Hei\} and Huo, \{Chu Ying\} and Jun Xu and Han, \{Quan Bin\} and Li, \{Li Feng\}",

note = "Funding information: This work was funded and supported by HKSAR Innovation and Technology Fund (ITF), Tier 3, ITS/311/09, General Research Fund (12100615, 22100014, 12100818, 12101322, 12101123), UGC Research Matching Grant Scheme (2019-1-10, 2019-1-14, 2019-2-06), Health Medical Research Fund (11122531, 14150521, 17182681), National Natural Science Foundation of China (81473341, 82173948, 82204747), the Science and Technology Project of Shenzhen (JCYJ20160531193812867), the Key-Area Research and Development Program of Guangdong Province (2020B1111110007), Hong Kong Baptist University (RC-Start-up Grants, MPCF-001-2016/2017, RC-IRMS/14-15/06, FRG2/17-18/060 and FRG2/16-17/002), and Vincent \& Lily Woo Foundation. Publisher Copyright: {\textcopyright} 2024 Elsevier B.V.",

year = "2024",

month = apr,

doi = "10.1016/j.ijbiomac.2024.130315",

language = "English",

volume = "263",

journal = "International Journal of Biological Macromolecules",

issn = "0141-8130",

publisher = "Elsevier B.V.",

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T1 - Critical review on the research of chemical structure, bioactivities, and mechanism of actions of Dendrobium officinale polysaccharide

AU - Lai, Cheuk Hei

AU - Huo, Chu Ying

AU - Xu, Jun

AU - Han, Quan Bin

AU - Li, Li Feng

N1 - Funding information: This work was funded and supported by HKSAR Innovation and Technology Fund (ITF), Tier 3, ITS/311/09, General Research Fund (12100615, 22100014, 12100818, 12101322, 12101123), UGC Research Matching Grant Scheme (2019-1-10, 2019-1-14, 2019-2-06), Health Medical Research Fund (11122531, 14150521, 17182681), National Natural Science Foundation of China (81473341, 82173948, 82204747), the Science and Technology Project of Shenzhen (JCYJ20160531193812867), the Key-Area Research and Development Program of Guangdong Province (2020B1111110007), Hong Kong Baptist University (RC-Start-up Grants, MPCF-001-2016/2017, RC-IRMS/14-15/06, FRG2/17-18/060 and FRG2/16-17/002), and Vincent & Lily Woo Foundation. Publisher Copyright: © 2024 Elsevier B.V.

PY - 2024/4

Y1 - 2024/4

N2 - Dendrobium officinale (Tie-Pi-Shi-Hu) is a precious traditional Chinese medicine (TCM). The principal active components are polysaccharides (DOP), which have a high potency in therapeutic applications. However, limitations in structure analysis and underlying mechanism investigation impede its further research. This review systemically and critically summarises current understanding in both areas, and points out the influence of starch impurities and the role of gut microbiota in DOP research. As challenges faced in studying natural polysaccharide investigations are common, this review contributes to a broader understanding of polysaccharides beyond DOP.

AB - Dendrobium officinale (Tie-Pi-Shi-Hu) is a precious traditional Chinese medicine (TCM). The principal active components are polysaccharides (DOP), which have a high potency in therapeutic applications. However, limitations in structure analysis and underlying mechanism investigation impede its further research. This review systemically and critically summarises current understanding in both areas, and points out the influence of starch impurities and the role of gut microbiota in DOP research. As challenges faced in studying natural polysaccharide investigations are common, this review contributes to a broader understanding of polysaccharides beyond DOP.

KW - Bioactivity

KW - Dendrobium officinale

KW - Gut microbiota

KW - Polysaccharides

KW - Structure analysis

UR - https://www.scopus.com/pages/publications/85185831901

UR - https://www.sciencedirect.com/science/article/pii/S0141813024011188?via%3Dihub

U2 - 10.1016/j.ijbiomac.2024.130315

DO - 10.1016/j.ijbiomac.2024.130315

M3 - Journal article

C2 - 38382782

AN - SCOPUS:85185831901

SN - 0141-8130

VL - 263

JO - International Journal of Biological Macromolecules

JF - International Journal of Biological Macromolecules

M1 - 130315

ER -

Critical review on the research of chemical structure, bioactivities, and mechanism of actions of Dendrobium officinale polysaccharide

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