TY - JOUR
T1 - Critical review on anti-obesity effects of phytochemicals through Wnt/β-catenin signaling pathway
AU - Luo, Jinhai
AU - Yu, Zhiling
AU - Tovar, Juscelino
AU - Nilsson, Anne
AU - Xu, Baojun
N1 - Funding Information:
This project is supported by National Natural Science Foundation of China (Project code: 32172198).
Publisher Copyright:
© 2022 Elsevier Ltd.
PY - 2022/10
Y1 - 2022/10
N2 - Phytochemicals have been used as one of the sources for the development of anti-obesity drugs. Plants are rich in a variety of bioactive compounds including polyphenols, saponins and terpenes. Phytochemicals inhibit adipocyte differentiation by inhibiting the transcription and translation of adipogenesis transcription factors such as C/EBPα and PPARγ. It has been proved that phytochemicals inhibit the genes and proteins associated with adipogenesis and lipid accumulation by activating Wnt/β-catenin signaling pathway. The activation of Wnt/β-catenin signaling pathway by phytochemicals is multi-target regulation, including the regulation of pathway critical factor β-catenin and its target gene, the downregulation of destruction complex, and the up-regulation of Wnt ligands, its cell surface receptor and Wnt antagonist. In this review, the literature on the anti-obesity effect of phytochemicals through Wnt/β-catenin signaling pathway is collected from Google Scholar, Scopus, PubMed, and Web of Science, and summarizes the regulation mechanism of phytochemicals in this pathway. As one of the alternative methods of weight loss drugs, Phytochemicals inhibit adipogenesis through Wnt/β-catenin signaling pathway. More progress in relevant fields may pose phytochemicals as the main source of anti-obesity treatment.
AB - Phytochemicals have been used as one of the sources for the development of anti-obesity drugs. Plants are rich in a variety of bioactive compounds including polyphenols, saponins and terpenes. Phytochemicals inhibit adipocyte differentiation by inhibiting the transcription and translation of adipogenesis transcription factors such as C/EBPα and PPARγ. It has been proved that phytochemicals inhibit the genes and proteins associated with adipogenesis and lipid accumulation by activating Wnt/β-catenin signaling pathway. The activation of Wnt/β-catenin signaling pathway by phytochemicals is multi-target regulation, including the regulation of pathway critical factor β-catenin and its target gene, the downregulation of destruction complex, and the up-regulation of Wnt ligands, its cell surface receptor and Wnt antagonist. In this review, the literature on the anti-obesity effect of phytochemicals through Wnt/β-catenin signaling pathway is collected from Google Scholar, Scopus, PubMed, and Web of Science, and summarizes the regulation mechanism of phytochemicals in this pathway. As one of the alternative methods of weight loss drugs, Phytochemicals inhibit adipogenesis through Wnt/β-catenin signaling pathway. More progress in relevant fields may pose phytochemicals as the main source of anti-obesity treatment.
KW - Anti-obesity
KW - C/EBPα
KW - Phytochemicals
KW - PPARγ
KW - Wnt/β-catenin signaling pathway
KW - β-catenin
UR - http://www.scopus.com/inward/record.url?scp=85138786196&partnerID=8YFLogxK
U2 - 10.1016/j.phrs.2022.106461
DO - 10.1016/j.phrs.2022.106461
M3 - Review article
C2 - 36152739
AN - SCOPUS:85138786196
SN - 1043-6618
VL - 184
JO - Pharmacological Research
JF - Pharmacological Research
M1 - 106461
ER -