Coupling factors and exosomal packaging microRNAs involved in the regulation of bone remodelling

Sipin Zhu, Felix Yao, Heng Qiu, Ge Zhang, Huazi Xu, Jiake Xu*

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

82 Citations (Scopus)


Bone remodelling is a continuous process by which bone resorption by osteoclasts is followed by bone formation by osteoblasts to maintain skeletal homeostasis. These two forces must be tightly coordinated not only quantitatively, but also in time and space, and its malfunction leads to diseases such as osteoporosis. Recent research focusing on the cross-talk and coupling mechanisms associated with the sequential recruitment of osteoblasts to areas where osteoclasts have removed bone matrix have identified a number of osteogenic factors produced by the osteoclasts themselves. Osteoclast-derived factors and exosomal-containing microRNA (miRNA) can either enhance or inhibit osteoblast differentiation through paracrine and juxtacrine mechanisms, and therefore may have a central coupling role in bone formation. Entwined with angiocrine factors released by vessel-specific endothelial cells and perivascular cells or pericytes, these factors play a critical role in angiogenesis–osteogenesis coupling essential in bone remodelling.

Original languageEnglish
Pages (from-to)469-480
Number of pages12
JournalBiological Reviews
Issue number1
Publication statusPublished - 1 Feb 2018

Scopus Subject Areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

User-Defined Keywords

  • angiogenesis
  • bone microenvironment
  • bone remodelling
  • coupling factor
  • exosomal microRNA
  • osteoblasts
  • osteoclasts
  • osteogenesis


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