Cortical haemodynamic response measured by functional near infrared spectroscopy during a verbal fluency task in patients with major depression and borderline personality disorder

Syeda F. Husain; Tong-Boon Tang; Rongjun Yu; Wilson W. Tam; Bach Tran; Travis T. Quek; Shi-Hui Hwang; Cheryl W. Chang; Cyrus S. Ho; Roger C. Ho

doi:10.1016/j.ebiom.2019.11.047

Cortical haemodynamic response measured by functional near infrared spectroscopy during a verbal fluency task in patients with major depression and borderline personality disorder

Syeda F. Husain, Tong-Boon Tang, Rongjun Yu, Wilson W. Tam, Bach Tran, Travis T. Quek, Shi-Hui Hwang, Cheryl W. Chang, Cyrus S. Ho, Roger C. Ho^*

^*Corresponding author for this work

Research output: Contribution to journal › Journal article › peer-review

129 Citations (Scopus)

Abstract

Background: Functional near infrared spectroscopy (fNIRS) provides a direct and quantitative assessment of cortical haemodynamic function during a cognitive task. This functional neuroimaging modality may be used to elucidate the pathophysiology of psychiatric disorders, and identify neurophysiological differences between co-occurring psychiatric disorders. However, fNIRS research on borderline personality disorder (BPD) has been limited. Hence, this study aimed to compare cerebral haemodynamic function in healthy controls (HC), patients with major depressive disorder (MDD) and patients with BPD.

Methods: fNIRS signals during a verbal fluency task designed for clinical assessment was recorded for all participants. Demographics, clinical history and symptom severity were also noted.

Findings: Compared to HCs (n = 31), both patient groups (MDD, n = 31; BPD, n = 31) displayed diminished haemodynamic response in the frontal, temporal and parietal cortices. Moreover, haemodynamic response in the right frontal cortex is markedly lower in patients with MDD compared to patients with BPD.

Interpretation: Normal cortical function in patients with BPD is disrupted, but not as extensively as in patients with MDD. These results provide further neurophysiological evidence for the distinction of patients with MDD from patients with BPD.

Original language	English
Article number	102586
Number of pages	16
Journal	EBioMedicine
Volume	51
Early online date	24 Dec 2019
DOIs	https://doi.org/10.1016/j.ebiom.2019.11.047
Publication status	Published - Jan 2020

User-Defined Keywords

Near-infrared spectroscopy
Verbal fluency task
Prefrontal cortex
Haemodynamic response
Borderline personality disorder
Major depressive disorder

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10.1016/j.ebiom.2019.11.047

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Husain, S. F., Tang, T.-B., Yu, R., Tam, W. W., Tran, B., Quek, T. T., Hwang, S.-H., Chang, C. W., Ho, C. S., & Ho, R. C. (2020). Cortical haemodynamic response measured by functional near infrared spectroscopy during a verbal fluency task in patients with major depression and borderline personality disorder. EBioMedicine, 51, Article 102586. https://doi.org/10.1016/j.ebiom.2019.11.047

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title = "Cortical haemodynamic response measured by functional near infrared spectroscopy during a verbal fluency task in patients with major depression and borderline personality disorder",

abstract = "Background: Functional near infrared spectroscopy (fNIRS) provides a direct and quantitative assessment of cortical haemodynamic function during a cognitive task. This functional neuroimaging modality may be used to elucidate the pathophysiology of psychiatric disorders, and identify neurophysiological differences between co-occurring psychiatric disorders. However, fNIRS research on borderline personality disorder (BPD) has been limited. Hence, this study aimed to compare cerebral haemodynamic function in healthy controls (HC), patients with major depressive disorder (MDD) and patients with BPD.Methods: fNIRS signals during a verbal fluency task designed for clinical assessment was recorded for all participants. Demographics, clinical history and symptom severity were also noted.Findings: Compared to HCs (n = 31), both patient groups (MDD, n = 31; BPD, n = 31) displayed diminished haemodynamic response in the frontal, temporal and parietal cortices. Moreover, haemodynamic response in the right frontal cortex is markedly lower in patients with MDD compared to patients with BPD.Interpretation: Normal cortical function in patients with BPD is disrupted, but not as extensively as in patients with MDD. These results provide further neurophysiological evidence for the distinction of patients with MDD from patients with BPD.",

keywords = "Near-infrared spectroscopy, Verbal fluency task, Prefrontal cortex, Haemodynamic response, Borderline personality disorder, Major depressive disorder",

author = "Husain, {Syeda F.} and Tong-Boon Tang and Rongjun Yu and Tam, {Wilson W.} and Bach Tran and Quek, {Travis T.} and Shi-Hui Hwang and Chang, {Cheryl W.} and Ho, {Cyrus S.} and Ho, {Roger C.}",

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year = "2020",

month = jan,

doi = "10.1016/j.ebiom.2019.11.047",

language = "English",

volume = "51",

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T1 - Cortical haemodynamic response measured by functional near infrared spectroscopy during a verbal fluency task in patients with major depression and borderline personality disorder

AU - Husain, Syeda F.

AU - Tang, Tong-Boon

AU - Yu, Rongjun

AU - Tam, Wilson W.

AU - Tran, Bach

AU - Quek, Travis T.

AU - Hwang, Shi-Hui

AU - Chang, Cheryl W.

AU - Ho, Cyrus S.

AU - Ho, Roger C.

PY - 2020/1

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N2 - Background: Functional near infrared spectroscopy (fNIRS) provides a direct and quantitative assessment of cortical haemodynamic function during a cognitive task. This functional neuroimaging modality may be used to elucidate the pathophysiology of psychiatric disorders, and identify neurophysiological differences between co-occurring psychiatric disorders. However, fNIRS research on borderline personality disorder (BPD) has been limited. Hence, this study aimed to compare cerebral haemodynamic function in healthy controls (HC), patients with major depressive disorder (MDD) and patients with BPD.Methods: fNIRS signals during a verbal fluency task designed for clinical assessment was recorded for all participants. Demographics, clinical history and symptom severity were also noted.Findings: Compared to HCs (n = 31), both patient groups (MDD, n = 31; BPD, n = 31) displayed diminished haemodynamic response in the frontal, temporal and parietal cortices. Moreover, haemodynamic response in the right frontal cortex is markedly lower in patients with MDD compared to patients with BPD.Interpretation: Normal cortical function in patients with BPD is disrupted, but not as extensively as in patients with MDD. These results provide further neurophysiological evidence for the distinction of patients with MDD from patients with BPD.

AB - Background: Functional near infrared spectroscopy (fNIRS) provides a direct and quantitative assessment of cortical haemodynamic function during a cognitive task. This functional neuroimaging modality may be used to elucidate the pathophysiology of psychiatric disorders, and identify neurophysiological differences between co-occurring psychiatric disorders. However, fNIRS research on borderline personality disorder (BPD) has been limited. Hence, this study aimed to compare cerebral haemodynamic function in healthy controls (HC), patients with major depressive disorder (MDD) and patients with BPD.Methods: fNIRS signals during a verbal fluency task designed for clinical assessment was recorded for all participants. Demographics, clinical history and symptom severity were also noted.Findings: Compared to HCs (n = 31), both patient groups (MDD, n = 31; BPD, n = 31) displayed diminished haemodynamic response in the frontal, temporal and parietal cortices. Moreover, haemodynamic response in the right frontal cortex is markedly lower in patients with MDD compared to patients with BPD.Interpretation: Normal cortical function in patients with BPD is disrupted, but not as extensively as in patients with MDD. These results provide further neurophysiological evidence for the distinction of patients with MDD from patients with BPD.

KW - Near-infrared spectroscopy

KW - Verbal fluency task

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KW - Haemodynamic response

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KW - Major depressive disorder

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DO - 10.1016/j.ebiom.2019.11.047

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Cortical haemodynamic response measured by functional near infrared spectroscopy during a verbal fluency task in patients with major depression and borderline personality disorder

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