Abstract
最近，我们合成了一系列Corrole衍生物，经过鼻咽癌(Nasopharyngeal carcinoma，NPC) 细胞的体外PDT试验后，筛选出了一个具有优良PDT活性的Corrole光敏剂。本文报道该类Corrole光敏剂在PDT中的重原子效应。
10-(2-Hydroxylphenyl)-5,15-bis(pentafluorophenyl) corrole was found to have a remarkable photocytotoxicity on nasopharyngeal carcinoma(NPC) cell line(Chang C. K. et al., Proc SPIE, 2006, Vol. 6139, p268). To explore the heavy-atom effect on corrole photosensitizer, an exact analogue of corole 1 with the modification of two heavy iodine atoms on its 10-phenyl group, 10-(2-hydroxyl-3,5-diiodophenyl)-5,15-bis(pentafluorophenyl)corrole, were synthesized.
| Translated title of the contribution | Heavy-atom effect of Corrole photosensitizer for photodynamic therapy |
|---|---|
| Original language | Chinese (Simplified) |
| Pages (from-to) | 1363-1365 |
| Number of pages | 3 |
| Journal | 高等学校化学学报 |
| Volume | 27 |
| Issue number | 7 |
| Publication status | Published - 10 Jul 2006 |
Scopus Subject Areas
- General Chemistry
User-Defined Keywords
- 光敏剂
- 鼻咽癌
- 光动力治疗
- 重原子效应
- Corrole
- Photosensitizer
- Nasopharyngeal carcinoma
- Photodynamic therapy
- Heavy-atom effect