Corni Fructus: A review of chemical constituents and pharmacological activities

Yu Dong, Zhe Ling Feng, Hubiao Chen, Fu Sheng Wang, Jia Hong Lu*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

90 Citations (Scopus)


Cornus officinalis Sieb. et Zucc. is part of the genus Cornus of the family Cornaceae. Ripening and dry fruits (Corni Fructus) are recognized as an essential herb medicine in the traditional Chinese medicine (TCM) and have been widely used for over 2000 years. This review provides a comprehensive summary of Corni Fructus (CF), including the botany, phytochemistry, traditional use, and current pharmacological activities. According to the basic theory of TCM, CF usually participates in various Chinese medicinal formulae to exert the essential roles in replenishing liver and kidney, arresting seminal emission and sweat. Based on modern pharmacological studies, about 90 compounds have been isolated and identified from CF. In vivo and in vitro experimental studies indicate that CF exhibits extensive pharmacological activities including hypoglycemic, antioxidant, anti-inflammatory, anticancer, neuroprotective, hepatoprotective, and nephroprotective activities. However, only about 18% of chemical constituents in CF were tested. It means the potential pharmacological activities and clinical values of CF need to be further investigated.

Original languageEnglish
Article number34
JournalChinese Medicine
Issue number1
Publication statusPublished - 25 Jun 2018

Scopus Subject Areas

  • Pharmacology
  • Complementary and alternative medicine

User-Defined Keywords

  • Corni Fructus
  • Cornus officinalis Sieb. et Zucc.
  • Pharmacological activity
  • Phytochemistry
  • Shan Zhu Yu


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