Coriatone and corianlactone, two novel sesquiterpenes from Coriaria nepalensis

Yun Heng Shen; Sheng Hong Li; Rong Tao Li; Quan Bin Han; Qin Shi Zhao; Li Liang; Han Dong Sun; Yang Lu; Peng Cao; Qi Tai Zheng

doi:10.1021/ol049660p

Coriatone and corianlactone, two novel sesquiterpenes from Coriaria nepalensis

Yun Heng Shen, Sheng Hong Li, Rong Tao Li, Quan Bin Han, Qin Shi Zhao, Li Liang, Han Dong Sun^*, Yang Lu, Peng Cao, Qi Tai Zheng

^*Corresponding author for this work

Chinese Medicine - Teaching and Research Division

Research output: Contribution to journal › Journal article › peer-review

24 Citations (Scopus)

Abstract

Both coriatone (1), a novel highly oxygenated picrotoxane-type sesquiterpene, and corianlactone (2), with an unprecedented sesquiterpene basic skeleton, named coriane, were isolated from Coriaria nepalensis Wall. The structures of 1 and 2 were determined by analysis of their two-dimensional NMR data, and the structure of 2 was confirmed by X-ray analysis. Compounds 1 and 2 showed no remarkable inhibitory activity toward K₅₆₂ cells. They are cytotoxic with IC₅₀ > 50 μg/mL (cis-platinim: IC₅₀ = 0.49 μg/mL).

Original language	English
Pages (from-to)	1593-1595
Number of pages	3
Journal	Organic Letters
Volume	6
Issue number	10
Early online date	14 Apr 2004
DOIs	https://doi.org/10.1021/ol049660p
Publication status	Published - 1 May 2004

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title = "Coriatone and corianlactone, two novel sesquiterpenes from Coriaria nepalensis",

abstract = "Both coriatone (1), a novel highly oxygenated picrotoxane-type sesquiterpene, and corianlactone (2), with an unprecedented sesquiterpene basic skeleton, named coriane, were isolated from Coriaria nepalensis Wall. The structures of 1 and 2 were determined by analysis of their two-dimensional NMR data, and the structure of 2 was confirmed by X-ray analysis. Compounds 1 and 2 showed no remarkable inhibitory activity toward K562 cells. They are cytotoxic with IC50 > 50 μg/mL (cis-platinim: IC50 = 0.49 μg/mL).",

author = "Shen, {Yun Heng} and Li, {Sheng Hong} and Li, {Rong Tao} and Han, {Quan Bin} and Zhao, {Qin Shi} and Li Liang and Sun, {Han Dong} and Yang Lu and Peng Cao and Zheng, {Qi Tai}",

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doi = "10.1021/ol049660p",

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T1 - Coriatone and corianlactone, two novel sesquiterpenes from Coriaria nepalensis

AU - Shen, Yun Heng

AU - Li, Sheng Hong

AU - Li, Rong Tao

AU - Han, Quan Bin

AU - Zhao, Qin Shi

AU - Liang, Li

AU - Sun, Han Dong

AU - Lu, Yang

AU - Cao, Peng

AU - Zheng, Qi Tai

PY - 2004/5/1

Y1 - 2004/5/1

N2 - Both coriatone (1), a novel highly oxygenated picrotoxane-type sesquiterpene, and corianlactone (2), with an unprecedented sesquiterpene basic skeleton, named coriane, were isolated from Coriaria nepalensis Wall. The structures of 1 and 2 were determined by analysis of their two-dimensional NMR data, and the structure of 2 was confirmed by X-ray analysis. Compounds 1 and 2 showed no remarkable inhibitory activity toward K562 cells. They are cytotoxic with IC50 > 50 μg/mL (cis-platinim: IC50 = 0.49 μg/mL).

AB - Both coriatone (1), a novel highly oxygenated picrotoxane-type sesquiterpene, and corianlactone (2), with an unprecedented sesquiterpene basic skeleton, named coriane, were isolated from Coriaria nepalensis Wall. The structures of 1 and 2 were determined by analysis of their two-dimensional NMR data, and the structure of 2 was confirmed by X-ray analysis. Compounds 1 and 2 showed no remarkable inhibitory activity toward K562 cells. They are cytotoxic with IC50 > 50 μg/mL (cis-platinim: IC50 = 0.49 μg/mL).

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U2 - 10.1021/ol049660p

DO - 10.1021/ol049660p

M3 - Journal article

SN - 1523-7060

VL - 6

SP - 1593

EP - 1595

JO - Organic Letters

JF - Organic Letters

IS - 10

ER -

Coriatone and corianlactone, two novel sesquiterpenes from Coriaria nepalensis

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