Coriatone and corianlactone, two novel sesquiterpenes from Coriaria nepalensis

Yun Heng Shen, Sheng Hong Li, Rong Tao Li, Quan Bin Han, Qin Shi Zhao, Li Liang, Han Dong Sun*, Yang Lu, Peng Cao, Qi Tai Zheng

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

23 Citations (Scopus)

Abstract

Both coriatone (1), a novel highly oxygenated picrotoxane-type sesquiterpene, and corianlactone (2), with an unprecedented sesquiterpene basic skeleton, named coriane, were isolated from Coriaria nepalensis Wall. The structures of 1 and 2 were determined by analysis of their two-dimensional NMR data, and the structure of 2 was confirmed by X-ray analysis. Compounds 1 and 2 showed no remarkable inhibitory activity toward K562 cells. They are cytotoxic with IC50 > 50 μg/mL (cis-platinim: IC50 = 0.49 μg/mL).

Original languageEnglish
Pages (from-to)1593-1595
Number of pages3
JournalOrganic Letters
Volume6
Issue number10
Early online date14 Apr 2004
DOIs
Publication statusPublished - 1 May 2004

Scopus Subject Areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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