@article{ddab2fa9f1c4447888ab2fc5f57c2819,
title = "Cordyceps polysaccharide marker CCP modulates immune responses via highly selective TLR4/MyD88/p38 axis",
abstract = "Cordyceps, one of the most expensive natural health supplements, is popularly used to modulate immune function. However, little is known regarding the underlying mechanism of its immunomodulatory activity. We newly reported a Cordyceps quality marker CCP (Mw 433.778 kDa) which was characterized as a 1,4-α glucan by chemical and spectral analysis and is able to induce significant immune responses of macrophages. Herein, we further investigated the molecular mechanism of CCP's immunomodulatory effects. The results indicate that CCP modulates the TLR4/MyD88/p38 signaling pathway of macrophages, where TLR4 plays a crucial role as verified on TLR4-deficient (TLR4−/−) bone marrow-derived macrophages (BMDMs) and TLR4−/− mice. These findings provide a precise understanding of the molecular mechanism of Cordyceps' immunomodulatory benefits.",
keywords = "Cordyceps, Immune responses, Macrophage, Polysaccharide, TLR4/MyD88/p38",
author = "Quanwei Zhang and Man Liu and Lifeng Li and Miaomiao Chen and Puno, {Pema Tenzin} and Wanrong Bao and Hongming Zheng and Xin Wen and Huiyuan Cheng and Hauyee Fung and Tinlong Wong and Zhongzhen Zhao and Aiping Lyu and Quanbin Han and Handong Sun",
note = "Funding Information: This work was funded and supported by HKSAR Innovation and Technology Fund (ITF), Tier 3, ITS/311/09 , General Research Fund ( 12100615 , 22100014 , 12100818 ), UGC Research Matching Grant Scheme ( 2019-1-10 , 2019-1-14 , 2019-2-06 ), Health Medical Research Fund ( 11122531 , 14150521 , 17182681 ), National Natural Sciences Foundation in China ( 81473341 ), the Science and Technology Project of Shenzhen ( JCYJ20160531193812867 ), the Key-Area Research and Development Program of Guangdong Province ( 2020B1111110007 ), Hong Kong Baptist University (RC-Start-up Grants, MPCF-001-2016/2017 , RC-IRMS/14-15/06 , FRG2/17-18/060 and FRG2/16-17/002 ), and Vincent & Lily Woo Foundation . Publisher Copyright: {\textcopyright} 2021",
year = "2021",
month = nov,
day = "1",
doi = "10.1016/j.carbpol.2021.118443",
language = "English",
volume = "271",
journal = "Carbohydrate Polymers",
issn = "0144-8617",
publisher = "Elsevier Ltd.",
}