Copper(II) triflate-catalyzed highly efficient synthesis of N-substituted 1,4-dihydropyridine derivatives via three-component cyclizations of alkynes, amines, and α,β-unsaturated aldehydes

Sifeng Li; Qingjing Yang; Jun Wang

doi:10.1016/j.tetlet.2016.08.085

Copper(II) triflate-catalyzed highly efficient synthesis of N-substituted 1,4-dihydropyridine derivatives via three-component cyclizations of alkynes, amines, and α,β-unsaturated aldehydes

Sifeng Li
, Qingjing Yang
, Jun Wang^*

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Journal article › peer-review

20 Citations (Scopus)

Abstract

A copper(II) triflate-catalyzed three-component cyclization of alkynes, amines, and α,β-unsaturated aldehydes was developed to give various 1,4-dihydropyridines in good to high yields. In addition, this efficient and practical protocol proceeded smoothly in gram scale even when the catalytic loading was reduced to 1 mol %.

Original language	English
Pages (from-to)	4500-4504
Number of pages	5
Journal	Tetrahedron Letters
Volume	57
Issue number	40
DOIs	https://doi.org/10.1016/j.tetlet.2016.08.085
Publication status	Published - 5 Oct 2016

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10.1016/j.tetlet.2016.08.085

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@article{0b650273a7fe4539a52af4fa5e026ea3,

title = "Copper(II) triflate-catalyzed highly efficient synthesis of N-substituted 1,4-dihydropyridine derivatives via three-component cyclizations of alkynes, amines, and α,β-unsaturated aldehydes",

abstract = "A copper(II) triflate-catalyzed three-component cyclization of alkynes, amines, and α,β-unsaturated aldehydes was developed to give various 1,4-dihydropyridines in good to high yields. In addition, this efficient and practical protocol proceeded smoothly in gram scale even when the catalytic loading was reduced to 1 mol \%.",

author = "Sifeng Li and Qingjing Yang and Jun Wang",

note = "We gratefully thank the startup fund from South University of Science and Technology of China and Shenzhen Basic Research Program (JCYJ20150630145302229) for financial support.",

year = "2016",

month = oct,

day = "5",

doi = "10.1016/j.tetlet.2016.08.085",

language = "English",

volume = "57",

pages = "4500--4504",

journal = "Tetrahedron Letters",

issn = "0040-4039",

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Copper(II) triflate-catalyzed highly efficient synthesis of N-substituted 1,4-dihydropyridine derivatives via three-component cyclizations of alkynes, amines, and α,β-unsaturated aldehydes. / Li, Sifeng; Yang, Qingjing; Wang, Jun.
In: Tetrahedron Letters, Vol. 57, No. 40, 05.10.2016, p. 4500-4504.

Research output: Contribution to journal › Journal article › peer-review

TY - JOUR

T1 - Copper(II) triflate-catalyzed highly efficient synthesis of N-substituted 1,4-dihydropyridine derivatives via three-component cyclizations of alkynes, amines, and α,β-unsaturated aldehydes

AU - Li, Sifeng

AU - Yang, Qingjing

AU - Wang, Jun

N1 - We gratefully thank the startup fund from South University of Science and Technology of China and Shenzhen Basic Research Program (JCYJ20150630145302229) for financial support.

PY - 2016/10/5

Y1 - 2016/10/5

N2 - A copper(II) triflate-catalyzed three-component cyclization of alkynes, amines, and α,β-unsaturated aldehydes was developed to give various 1,4-dihydropyridines in good to high yields. In addition, this efficient and practical protocol proceeded smoothly in gram scale even when the catalytic loading was reduced to 1 mol %.

AB - A copper(II) triflate-catalyzed three-component cyclization of alkynes, amines, and α,β-unsaturated aldehydes was developed to give various 1,4-dihydropyridines in good to high yields. In addition, this efficient and practical protocol proceeded smoothly in gram scale even when the catalytic loading was reduced to 1 mol %.

U2 - 10.1016/j.tetlet.2016.08.085

DO - 10.1016/j.tetlet.2016.08.085

M3 - Journal article

SN - 0040-4039

VL - 57

SP - 4500

EP - 4504

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 40

ER -

Copper(II) triflate-catalyzed highly efficient synthesis of N-substituted 1,4-dihydropyridine derivatives via three-component cyclizations of alkynes, amines, and α,β-unsaturated aldehydes

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