Copper(II) triflate-catalyzed highly efficient synthesis of N-substituted 1,4-dihydropyridine derivatives via three-component cyclizations of alkynes, amines, and α,β-unsaturated aldehydes

Sifeng Li, Qingjing Yang, Jun Wang

Research output: Contribution to journalArticlepeer-review

Abstract

A copper(II) triflate-catalyzed three-component cyclization of alkynes, amines, and α,β-unsaturated aldehydes was developed to give various 1,4-dihydropyridines in good to high yields. In addition, this efficient and practical protocol proceeded smoothly in gram scale even when the catalytic loading was reduced to 1 mol %.
Original languageEnglish
Pages (from-to)4500-4504
Number of pages5
JournalTetrahedron Letters
Volume57
Issue number40
DOIs
Publication statusPublished - 5 Oct 2016

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