Copper-Mediated Remote C-H Bond Chalcogenation of Quinolines on the C5 Position

Longzhi Zhu, Renhua Qiu*, Xin Cao, Song Xiao, Xinhua Xu, Chak Tong Au, Shuang Feng Yin*

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

130 Citations (Scopus)


An efficient and convenient method is developed for the remote C-H bond chalcogenation of 8-aminoquinoline scaffolds on the C5 position that is geometrically inaccessible. The protocol makes use of inexpensive CuBr2 as mediator and shows good tolerance toward numerous disulfides/diselenides and aliphatic amides, giving the corresponding products in good to excellent yield.

Original languageEnglish
Pages (from-to)5528-5531
Number of pages4
JournalOrganic Letters
Issue number22
Publication statusPublished - 20 Nov 2015

Scopus Subject Areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry


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