Convenient method for modifying poly(dimethylsiloxane) with poly(ethylene glycol) in microfluidics

Jianhua Zhou, Hui Yan, Kangning Ren, Wen Dai, Hongkai Wu*

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

66 Citations (Scopus)


This report describes a convenient and reproducible method for the covalent modification of poly(dimethylsiloxane) (PDMS) with poly(ethylene glycol) (PEG) chains to suppress nonspecific protein adsorption. PEG additives terminated with a vinyl group are added into the PDMS prepolymer; when the PDMS is thermally cured, the vinyl group reacts with the silane groups on the PDMS, which covalently link the PEG group to the PDMS network. The PEG-modified PDMS surfaces are characterized with FTIR, X-ray photoelectron spectroscopy (XPS), and contact angle measurement. We also examined the modified PDMS for on-chip capillary electrophoresis and its capability of resisting nonspecific protein adsorption using bovine serum albumin (BSA) as a model. Based on our study, a molecular mechanism is given to successfully explain the surface properties of the modified PDMS surfaces.

Original languageEnglish
Pages (from-to)6627-6632
Number of pages6
JournalAnalytical Chemistry
Issue number16
Early online date14 Jul 2009
Publication statusPublished - 15 Aug 2009

Scopus Subject Areas

  • Analytical Chemistry


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