Convenient method for modifying poly(dimethylsiloxane) with poly(ethylene glycol) in microfluidics

Jianhua Zhou; Hui Yan; Kangning Ren; Wen Dai; Hongkai Wu

doi:10.1021/ac900551m

Convenient method for modifying poly(dimethylsiloxane) with poly(ethylene glycol) in microfluidics

Jianhua Zhou, Hui Yan, Kangning Ren, Wen Dai, Hongkai Wu^*

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Journal article › peer-review

66 Citations (Scopus)

Abstract

This report describes a convenient and reproducible method for the covalent modification of poly(dimethylsiloxane) (PDMS) with poly(ethylene glycol) (PEG) chains to suppress nonspecific protein adsorption. PEG additives terminated with a vinyl group are added into the PDMS prepolymer; when the PDMS is thermally cured, the vinyl group reacts with the silane groups on the PDMS, which covalently link the PEG group to the PDMS network. The PEG-modified PDMS surfaces are characterized with FTIR, X-ray photoelectron spectroscopy (XPS), and contact angle measurement. We also examined the modified PDMS for on-chip capillary electrophoresis and its capability of resisting nonspecific protein adsorption using bovine serum albumin (BSA) as a model. Based on our study, a molecular mechanism is given to successfully explain the surface properties of the modified PDMS surfaces.

Original language	English
Pages (from-to)	6627-6632
Number of pages	6
Journal	Analytical Chemistry
Volume	81
Issue number	16
Early online date	14 Jul 2009
DOIs	https://doi.org/10.1021/ac900551m
Publication status	Published - 15 Aug 2009

Scopus Subject Areas

Analytical Chemistry

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10.1021/ac900551m

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title = "Convenient method for modifying poly(dimethylsiloxane) with poly(ethylene glycol) in microfluidics",

abstract = "This report describes a convenient and reproducible method for the covalent modification of poly(dimethylsiloxane) (PDMS) with poly(ethylene glycol) (PEG) chains to suppress nonspecific protein adsorption. PEG additives terminated with a vinyl group are added into the PDMS prepolymer; when the PDMS is thermally cured, the vinyl group reacts with the silane groups on the PDMS, which covalently link the PEG group to the PDMS network. The PEG-modified PDMS surfaces are characterized with FTIR, X-ray photoelectron spectroscopy (XPS), and contact angle measurement. We also examined the modified PDMS for on-chip capillary electrophoresis and its capability of resisting nonspecific protein adsorption using bovine serum albumin (BSA) as a model. Based on our study, a molecular mechanism is given to successfully explain the surface properties of the modified PDMS surfaces.",

author = "Jianhua Zhou and Hui Yan and Kangning Ren and Wen Dai and Hongkai Wu",

note = "This work was supported by the DuPont Young Professor Award and Hong Kong UGC(DAG07/08.SC01 and WMINST08/ 09.SC02). ",

year = "2009",

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doi = "10.1021/ac900551m",

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T1 - Convenient method for modifying poly(dimethylsiloxane) with poly(ethylene glycol) in microfluidics

AU - Zhou, Jianhua

AU - Yan, Hui

AU - Ren, Kangning

AU - Dai, Wen

AU - Wu, Hongkai

N1 - This work was supported by the DuPont Young Professor Award and Hong Kong UGC(DAG07/08.SC01 and WMINST08/ 09.SC02).

PY - 2009/8/15

Y1 - 2009/8/15

N2 - This report describes a convenient and reproducible method for the covalent modification of poly(dimethylsiloxane) (PDMS) with poly(ethylene glycol) (PEG) chains to suppress nonspecific protein adsorption. PEG additives terminated with a vinyl group are added into the PDMS prepolymer; when the PDMS is thermally cured, the vinyl group reacts with the silane groups on the PDMS, which covalently link the PEG group to the PDMS network. The PEG-modified PDMS surfaces are characterized with FTIR, X-ray photoelectron spectroscopy (XPS), and contact angle measurement. We also examined the modified PDMS for on-chip capillary electrophoresis and its capability of resisting nonspecific protein adsorption using bovine serum albumin (BSA) as a model. Based on our study, a molecular mechanism is given to successfully explain the surface properties of the modified PDMS surfaces.

AB - This report describes a convenient and reproducible method for the covalent modification of poly(dimethylsiloxane) (PDMS) with poly(ethylene glycol) (PEG) chains to suppress nonspecific protein adsorption. PEG additives terminated with a vinyl group are added into the PDMS prepolymer; when the PDMS is thermally cured, the vinyl group reacts with the silane groups on the PDMS, which covalently link the PEG group to the PDMS network. The PEG-modified PDMS surfaces are characterized with FTIR, X-ray photoelectron spectroscopy (XPS), and contact angle measurement. We also examined the modified PDMS for on-chip capillary electrophoresis and its capability of resisting nonspecific protein adsorption using bovine serum albumin (BSA) as a model. Based on our study, a molecular mechanism is given to successfully explain the surface properties of the modified PDMS surfaces.

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U2 - 10.1021/ac900551m

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JO - Analytical Chemistry

JF - Analytical Chemistry

IS - 16

ER -

Convenient method for modifying poly(dimethylsiloxane) with poly(ethylene glycol) in microfluidics

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