Contrast-Enhanced MRI and Micro-CT Adopted for Evaluation of a Lipid-Lowering and Anticoagulant Herbal Epimedium-Derived Phytoestrogenic Extract for Prevention of Steroid-Associated Osteonecrosis

Ling Qin; Ge Zhang; Hui Sheng; James F. Griffth; Ka Wai Yeung; Kwok Sui Leung

doi:10.1007/978-3-540-45456-4_38

Contrast-Enhanced MRI and Micro-CT Adopted for Evaluation of a Lipid-Lowering and Anticoagulant Herbal Epimedium-Derived Phytoestrogenic Extract for Prevention of Steroid-Associated Osteonecrosis

Ling Qin^*
, Ge Zhang
, Hui Sheng
, James F. Griffth
, Ka Wai Yeung
, Kwok Sui Leung

^*Corresponding author for this work

Chinese Medicine - Teaching and Research Division

Research output: Chapter in book/report/conference proceeding › Chapter › peer-review

2 Citations (Scopus)

Abstract

We developed an alternative steroid-associated osteonecrosis (ON) rabbit model using a combination of a single injection of low-dose lipopolysaccharide (LPS) and three subsequent injections of pulsed high-dose methylprednisolone (MPS).The usefulness of this experimental ON model was evaluated using both conventional and advanced bio-imaging techniques, including contrast-enhanced dynamic MRI and a high-resolution micro-CT. Details on establishment of methodology are described, which were adopted into an efficacy study on a herbal Epimedium-derived phytoestrogenic extract (HEPE) developed for prevention of steroid-associated ON using an established rabbit model. The underlying mechanisms of HEPE for prevention of steroid-associated ON were found to be associated with inhibition of both intravascular thrombosis and extravascular bone marrow lipid deposition, the two known mechanistic pathways in pathogenesis of ON. Our experimental results provide for potential clinical trials or applications of HEPE in the prevention of ON among hig-hrisk patients undergoing steroid treatment.

Original language	English
Title of host publication	Advanced Bioimaging Technologies in Assessment of the Quality of Bone and Scaffold Materials
Subtitle of host publication	Techniques and Applications
Editors	Ling Qin, Harry K. Genant, James F. Griffith, Kwok Sui Leung
Publisher	Springer Berlin Heidelberg
Pages	593-611
Number of pages	19
Edition	1st
ISBN (Electronic)	9783540454564
ISBN (Print)	9783540454540, 9783642079559
DOIs	https://doi.org/10.1007/978-3-540-45456-4_38
Publication status	Published - 28 Jul 2007

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

User-Defined Keywords

Severe Acute Respiratory Syndrome
Severe Acute Respiratory Syndrome Patient
Lead Chromate
Pulse Steroid Treatment

Access to Document

10.1007/978-3-540-45456-4_38

Cite this

Qin, L., Zhang, G., Sheng, H., Griffth, J. F., Yeung, K. W., & Leung, K. S. (2007). Contrast-Enhanced MRI and Micro-CT Adopted for Evaluation of a Lipid-Lowering and Anticoagulant Herbal Epimedium-Derived Phytoestrogenic Extract for Prevention of Steroid-Associated Osteonecrosis. In L. Qin, H. K. Genant, J. F. Griffith, & K. S. Leung (Eds.), Advanced Bioimaging Technologies in Assessment of the Quality of Bone and Scaffold Materials: Techniques and Applications (1st ed., pp. 593-611). Springer Berlin Heidelberg. https://doi.org/10.1007/978-3-540-45456-4_38

Qin, Ling ; Zhang, Ge ; Sheng, Hui et al. / Contrast-Enhanced MRI and Micro-CT Adopted for Evaluation of a Lipid-Lowering and Anticoagulant Herbal Epimedium-Derived Phytoestrogenic Extract for Prevention of Steroid-Associated Osteonecrosis. Advanced Bioimaging Technologies in Assessment of the Quality of Bone and Scaffold Materials: Techniques and Applications. editor / Ling Qin ; Harry K. Genant ; James F. Griffith ; Kwok Sui Leung. 1st. ed. Springer Berlin Heidelberg, 2007. pp. 593-611

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title = "Contrast-Enhanced MRI and Micro-CT Adopted for Evaluation of a Lipid-Lowering and Anticoagulant Herbal Epimedium-Derived Phytoestrogenic Extract for Prevention of Steroid-Associated Osteonecrosis",

abstract = "We developed an alternative steroid-associated osteonecrosis (ON) rabbit model using a combination of a single injection of low-dose lipopolysaccharide (LPS) and three subsequent injections of pulsed high-dose methylprednisolone (MPS).The usefulness of this experimental ON model was evaluated using both conventional and advanced bio-imaging techniques, including contrast-enhanced dynamic MRI and a high-resolution micro-CT. Details on establishment of methodology are described, which were adopted into an efficacy study on a herbal Epimedium-derived phytoestrogenic extract (HEPE) developed for prevention of steroid-associated ON using an established rabbit model. The underlying mechanisms of HEPE for prevention of steroid-associated ON were found to be associated with inhibition of both intravascular thrombosis and extravascular bone marrow lipid deposition, the two known mechanistic pathways in pathogenesis of ON. Our experimental results provide for potential clinical trials or applications of HEPE in the prevention of ON among hig-hrisk patients undergoing steroid treatment.",

keywords = "Severe Acute Respiratory Syndrome, Severe Acute Respiratory Syndrome Patient, Lead Chromate, Pulse Steroid Treatment",

author = "Ling Qin and Ge Zhang and Hui Sheng and Griffth, \{James F.\} and Yeung, \{Ka Wai\} and Leung, \{Kwok Sui\}",

note = "This study was supported by a Direct Research Grant of the Chinese University of Hong Kong project ID ref. 6901559) and RGC (CUHK4503/06M). Publisher copyright: {\textcopyright} 2007 Springer-Verlag Berlin Heidelberg",

year = "2007",

month = jul,

day = "28",

doi = "10.1007/978-3-540-45456-4\_38",

language = "English",

isbn = "9783540454540",

pages = "593--611",

editor = "Ling Qin and Genant, \{Harry K.\} and Griffith, \{James F.\} and Leung, \{Kwok Sui\}",

booktitle = "Advanced Bioimaging Technologies in Assessment of the Quality of Bone and Scaffold Materials",

publisher = "Springer Berlin Heidelberg",

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Qin, L, Zhang, G, Sheng, H, Griffth, JF, Yeung, KW & Leung, KS 2007, Contrast-Enhanced MRI and Micro-CT Adopted for Evaluation of a Lipid-Lowering and Anticoagulant Herbal Epimedium-Derived Phytoestrogenic Extract for Prevention of Steroid-Associated Osteonecrosis. in L Qin, HK Genant, JF Griffith & KS Leung (eds), Advanced Bioimaging Technologies in Assessment of the Quality of Bone and Scaffold Materials: Techniques and Applications. 1st edn, Springer Berlin Heidelberg, pp. 593-611. https://doi.org/10.1007/978-3-540-45456-4_38

Contrast-Enhanced MRI and Micro-CT Adopted for Evaluation of a Lipid-Lowering and Anticoagulant Herbal Epimedium-Derived Phytoestrogenic Extract for Prevention of Steroid-Associated Osteonecrosis. / Qin, Ling; Zhang, Ge; Sheng, Hui et al.
Advanced Bioimaging Technologies in Assessment of the Quality of Bone and Scaffold Materials: Techniques and Applications. ed. / Ling Qin; Harry K. Genant; James F. Griffith; Kwok Sui Leung. 1st. ed. Springer Berlin Heidelberg, 2007. p. 593-611.

Research output: Chapter in book/report/conference proceeding › Chapter › peer-review

TY - CHAP

T1 - Contrast-Enhanced MRI and Micro-CT Adopted for Evaluation of a Lipid-Lowering and Anticoagulant Herbal Epimedium-Derived Phytoestrogenic Extract for Prevention of Steroid-Associated Osteonecrosis

AU - Qin, Ling

AU - Zhang, Ge

AU - Sheng, Hui

AU - Griffth, James F.

AU - Yeung, Ka Wai

AU - Leung, Kwok Sui

N1 - This study was supported by a Direct Research Grant of the Chinese University of Hong Kong project ID ref. 6901559) and RGC (CUHK4503/06M). Publisher copyright: © 2007 Springer-Verlag Berlin Heidelberg

PY - 2007/7/28

Y1 - 2007/7/28

N2 - We developed an alternative steroid-associated osteonecrosis (ON) rabbit model using a combination of a single injection of low-dose lipopolysaccharide (LPS) and three subsequent injections of pulsed high-dose methylprednisolone (MPS).The usefulness of this experimental ON model was evaluated using both conventional and advanced bio-imaging techniques, including contrast-enhanced dynamic MRI and a high-resolution micro-CT. Details on establishment of methodology are described, which were adopted into an efficacy study on a herbal Epimedium-derived phytoestrogenic extract (HEPE) developed for prevention of steroid-associated ON using an established rabbit model. The underlying mechanisms of HEPE for prevention of steroid-associated ON were found to be associated with inhibition of both intravascular thrombosis and extravascular bone marrow lipid deposition, the two known mechanistic pathways in pathogenesis of ON. Our experimental results provide for potential clinical trials or applications of HEPE in the prevention of ON among hig-hrisk patients undergoing steroid treatment.

AB - We developed an alternative steroid-associated osteonecrosis (ON) rabbit model using a combination of a single injection of low-dose lipopolysaccharide (LPS) and three subsequent injections of pulsed high-dose methylprednisolone (MPS).The usefulness of this experimental ON model was evaluated using both conventional and advanced bio-imaging techniques, including contrast-enhanced dynamic MRI and a high-resolution micro-CT. Details on establishment of methodology are described, which were adopted into an efficacy study on a herbal Epimedium-derived phytoestrogenic extract (HEPE) developed for prevention of steroid-associated ON using an established rabbit model. The underlying mechanisms of HEPE for prevention of steroid-associated ON were found to be associated with inhibition of both intravascular thrombosis and extravascular bone marrow lipid deposition, the two known mechanistic pathways in pathogenesis of ON. Our experimental results provide for potential clinical trials or applications of HEPE in the prevention of ON among hig-hrisk patients undergoing steroid treatment.

KW - Severe Acute Respiratory Syndrome

KW - Severe Acute Respiratory Syndrome Patient

KW - Lead Chromate

KW - Pulse Steroid Treatment

UR - https://www.scopus.com/pages/publications/84885801315

U2 - 10.1007/978-3-540-45456-4_38

DO - 10.1007/978-3-540-45456-4_38

M3 - Chapter

AN - SCOPUS:84885801315

SN - 9783540454540

SN - 9783642079559

SP - 593

EP - 611

BT - Advanced Bioimaging Technologies in Assessment of the Quality of Bone and Scaffold Materials

A2 - Qin, Ling

A2 - Genant, Harry K.

A2 - Griffith, James F.

A2 - Leung, Kwok Sui

PB - Springer Berlin Heidelberg

ER -

Qin L, Zhang G, Sheng H, Griffth JF, Yeung KW, Leung KS. Contrast-Enhanced MRI and Micro-CT Adopted for Evaluation of a Lipid-Lowering and Anticoagulant Herbal Epimedium-Derived Phytoestrogenic Extract for Prevention of Steroid-Associated Osteonecrosis. In Qin L, Genant HK, Griffith JF, Leung KS, editors, Advanced Bioimaging Technologies in Assessment of the Quality of Bone and Scaffold Materials: Techniques and Applications. 1st ed. Springer Berlin Heidelberg. 2007. p. 593-611 doi: 10.1007/978-3-540-45456-4_38

Contrast-Enhanced MRI and Micro-CT Adopted for Evaluation of a Lipid-Lowering and Anticoagulant Herbal Epimedium-Derived Phytoestrogenic Extract for Prevention of Steroid-Associated Osteonecrosis

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