Constructive effects of fluctuations in genetic and biochemical regulatory systems

Ralf Steuer*, Changsong ZHOU, Jürgen Kurths

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

50 Citations (Scopus)


Biochemical and genetic regulatory systems that involve low concentrations of molecules are inherently noisy. This intrinsic stochasticity has received considerable interest recently, leading to new insights about the sources and consequences of noise in complex systems of genetic regulation. However, most prior work was devoted to the reduction of fluctuation and the robustness of cellular function with respect to intrinsic noise. Here, we focus on several scenarios in which the inherent molecular fluctuations are not merely a nuisance, but act constructively and bring about qualitative changes in the dynamics of the system. It will be demonstrated that in many typical situations biochemical and genetic regulatory systems may utilize intrinsic noise to their advantage.

Original languageEnglish
Pages (from-to)241-251
Number of pages11
Issue number3
Publication statusPublished - Dec 2003

Scopus Subject Areas

  • Statistics and Probability
  • Modelling and Simulation
  • Biochemistry, Genetics and Molecular Biology(all)
  • Applied Mathematics

User-Defined Keywords

  • Circadian rhythms
  • Coherence resonance
  • Robustness
  • Stochastic modeling


Dive into the research topics of 'Constructive effects of fluctuations in genetic and biochemical regulatory systems'. Together they form a unique fingerprint.

Cite this