@article{54eb110126c24ba8bf37d2df8b5c7b63,
title = "Construction of 4-hydroxycoumarin derivatives with adjacent quaternary and tertiary stereocenters via ternary catalysis",
abstract = "4-Hydroxycoumarin derivatives represent one of the most important scaffolds in biologically active substances, pharmaceuticals and functional materials. Herein, we describe an efficient Pd/amine/Br{\o}nsted acid ternary-catalytic multicomponent reaction for the rapid construction of substituted 4-hydroxycoumarin derivatives with adjacent quaternary and tertiary stereocenters via convergent assembly of two in situ generated active intermediates. Furthermore, the late-stage transformations of coumarin derivatives and their in vitro trial of antitumor activity successfully demonstrated the potential utilities of the products as platform molecules.",
author = "Mengchu Zhang and Tianyuan Zhang and Sifan YU and Huang Qiu and Abdullah Yusuf and Xinfang Xu and Yu Qian and Wenhao Hu",
note = "Support for this research from the National Natural Science Foundation of China (92056201, 22171294, 81973176, 22001268), the Natural Science Foundation of Guangdong Province, China (2021A1515010401), Key-Area Research and Development Program of Guangdong Province (2022B1111050003), Guangdong Provincial Key Laboratory of Construction Foundation (2023B1212060022), Guangdong Natural Science Fund (2023A1515011486) and the Key Laboratory Open Project of Xinjiang Uygur Autonomous Region (2021D04018) is gratefully acknowledged. Publisher Copyright: {\textcopyright} 2023 The Author(s). Published by the Royal Society of Chemistry",
year = "2023",
month = nov,
day = "14",
doi = "10.1039/D3SC03452F",
language = "English",
volume = "42",
pages = "11850--11857",
journal = "Chemical Science",
issn = "2041-6520",
publisher = "Royal Society of Chemistry",
}
