Abstract
A constrained unidimensional scaling model where the objects are required to be placed in a given order on the real line, is studied. A procedure formulated as a least squares problem with nonnegativity is considered to solve this problem. An application to linkage disequilibrium (LD) maps for human genome is presented to demonstrate the proposed model. The LD maps are also constructed for four populations from Hapmap data sets, and analyze some of their similarities.
Original language | English |
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Pages (from-to) | 201-210 |
Number of pages | 10 |
Journal | Computational Statistics and Data Analysis |
Volume | 52 |
Issue number | 1 |
DOIs | |
Publication status | Published - 15 Sept 2007 |
User-Defined Keywords
- Constraints
- Genomics
- Least squares problem
- Linkage disequilibrium
- Nonnegativity
- Unidimensional scaling