TY - JOUR
T1 - Connective Tissue Growth Factor
T2 - Regulation, Diseases, and Drug Discovery
AU - Ren, Meishen
AU - Yao, Shanshan
AU - Chen, Tienan
AU - Luo, Hang
AU - Tao, Xiaohui
AU - Jiang, Hewen
AU - Yang, Xin
AU - Zhang, Huarui
AU - Yu, Sifan
AU - Wang, Yin
AU - Lu, Aiping
AU - Zhang, Ge
N1 - This work was supported by the Provincial Natural Science Foundation of Sichuan (2023NSFSC1216); The China Postdoctoral Science Foundation (2022M722300); The Hong Kong Scholars Program 2022, China Postdoctoral Science Foundation (XJ2022047); The Sichuan Province Science and Technology Planning Program (2021ZDZX0010).
Publisher Copyright:
© 2024 by the authors.
PY - 2024/5/1
Y1 - 2024/5/1
N2 - In drug discovery, selecting targeted molecules is crucial as the target could directly affect drug efficacy and the treatment outcomes. As a member of the CCN family, CTGF (also known as CCN2) is an essential regulator in the progression of various diseases, including fibrosis, cancer, neurological disorders, and eye diseases. Understanding the regulatory mechanisms of CTGF in different diseases may contribute to the discovery of novel drug candidates. Summarizing the CTGF-targeting and -inhibitory drugs is also beneficial for the analysis of the efficacy, applications, and limitations of these drugs in different disease models. Therefore, we reviewed the CTGF structure, the regulatory mechanisms in various diseases, and drug development in order to provide more references for future drug discovery.
AB - In drug discovery, selecting targeted molecules is crucial as the target could directly affect drug efficacy and the treatment outcomes. As a member of the CCN family, CTGF (also known as CCN2) is an essential regulator in the progression of various diseases, including fibrosis, cancer, neurological disorders, and eye diseases. Understanding the regulatory mechanisms of CTGF in different diseases may contribute to the discovery of novel drug candidates. Summarizing the CTGF-targeting and -inhibitory drugs is also beneficial for the analysis of the efficacy, applications, and limitations of these drugs in different disease models. Therefore, we reviewed the CTGF structure, the regulatory mechanisms in various diseases, and drug development in order to provide more references for future drug discovery.
KW - CTGF-related diseases
KW - CTGF/CCN2
KW - drug discovery
KW - regulation mechanism
KW - therapeutic target
UR - http://www.scopus.com/inward/record.url?scp=85192700180&partnerID=8YFLogxK
U2 - 10.3390/ijms25094692
DO - 10.3390/ijms25094692
M3 - Review article
C2 - 38731911
AN - SCOPUS:85192700180
SN - 1661-6596
VL - 25
JO - International Journal of Molecular Sciences
JF - International Journal of Molecular Sciences
IS - 9
M1 - 4692
ER -
