TY - JOUR
T1 - Concentrations of organochlorine pesticides (OCPs) in human blood plasma from Hong Kong
T2 - Markers of exposure and sources from fish
AU - Wang, Hong Sheng
AU - Chen, Zhuo Jia
AU - Wei, Wei
AU - Man, Yu Bon
AU - Giesy, John P.
AU - Du, Jun
AU - Zhang, Ge
AU - WONG, Chris K C
AU - WONG, Ming Hung
N1 - Funding Information:
This research was supported by the China Postdoctoral Science Foundation (No. 2012M511868 ), the Seed Collaborative Research Fund from the State Key Laboratory in Marine Pollution ( SCRF0003 ), the Fundamental Research Funds for the Central Universities (Sun Yat-sen University) (No. 12ykpy09 ), the National Natural Science Foundation of China (No. 31101071 ), the Science and Technology Planning Project of Guangdong Province, China (No. 2012B031500005 ), and the Research Grants Council of the University Grants Committee of Hong Kong (Collaborative Research Fund, HKBU1/CRF/08 and Special Equipment Grant, HKBU09 ). The research was supported, in part, by a Discovery Grant from the Natural Science and Engineering Research Council of Canada (Project # 326415-07 ). Prof. Giesy was supported by the program of 2012 “ High Level Foreign Experts ” (# GDW20123200120 ) funded by the State Administration of Foreign Experts Affairs , the P.R. China to Nanjing University and the Einstein Professor Program of the Chinese Academy of Sciences . He was also supported by the Canada Research Chair Program , an at large Chair Professorship at the Department of Biology and Chemistry and State Key Laboratory in Marine Pollution, City University of Hong Kong .
PY - 2013/4
Y1 - 2013/4
N2 - Previous studies revealed that food, particularly fish products, is the major source for human exposure to organochlorine pesticides (OCPs). Our previous studies revealed that contamination of Hong Kong market fish with DDT was 0.74-131 with a mean of 12.2ngg-1, ww, a result suggested that local people might be exposed to hazardous concentrations of OCPs. Therefore, the present systematic study was conducted to determine concentrations of OCPs in blood plasma of Hong Kong residents, develop marker substances and evaluate sources of 19 individual OCPs from fish. Concentrations of ∑OCPs, ∑DDTs and ∑HCHs ranged from 294 to 9732, 172 to 8842, and 115 to 1616ngg-1 lipid weight (lw), respectively. These concentrations were greater than those in blood of people from most developed countries but lower than those from most developing countries. The upper age group (>50years) had significant (p<0.05) greater concentrations of OCPs than other groups. Furthermore, concentrations of OCPs in males were significantly (p<0.05) greater than those in females. p, p'-DDE was the predominant congener and marker substance of DDTs, while β-HCH was the predominant congener and marker substance of HCHs. p, p'-DDE was more correlated with ∑OCPs (r2=0.830, p<0.05) than other individual OCPs, which suggested that p, p'-DDE is a good marker for accumulation of OCPs in blood plasma. Concentrations of individual OCPs were significantly correlated with not only their corresponding total concentrations in fishes from Hong Kong markets (r2=0.391, p=0.024), but also their bioaccessible fractions, which were estimated by an in vitro digestion method (r2=0.784, p=0.000). These results suggested that the in vitro gastrointestinal model is a more accurate method to evaluate accumulation of and health risks caused by dietary intake of OCPs. This study, which was the first systematic study to investigate concentrations of OCPs in blood of Hong Kong people, provides a baseline to which future measurements can be compared.
AB - Previous studies revealed that food, particularly fish products, is the major source for human exposure to organochlorine pesticides (OCPs). Our previous studies revealed that contamination of Hong Kong market fish with DDT was 0.74-131 with a mean of 12.2ngg-1, ww, a result suggested that local people might be exposed to hazardous concentrations of OCPs. Therefore, the present systematic study was conducted to determine concentrations of OCPs in blood plasma of Hong Kong residents, develop marker substances and evaluate sources of 19 individual OCPs from fish. Concentrations of ∑OCPs, ∑DDTs and ∑HCHs ranged from 294 to 9732, 172 to 8842, and 115 to 1616ngg-1 lipid weight (lw), respectively. These concentrations were greater than those in blood of people from most developed countries but lower than those from most developing countries. The upper age group (>50years) had significant (p<0.05) greater concentrations of OCPs than other groups. Furthermore, concentrations of OCPs in males were significantly (p<0.05) greater than those in females. p, p'-DDE was the predominant congener and marker substance of DDTs, while β-HCH was the predominant congener and marker substance of HCHs. p, p'-DDE was more correlated with ∑OCPs (r2=0.830, p<0.05) than other individual OCPs, which suggested that p, p'-DDE is a good marker for accumulation of OCPs in blood plasma. Concentrations of individual OCPs were significantly correlated with not only their corresponding total concentrations in fishes from Hong Kong markets (r2=0.391, p=0.024), but also their bioaccessible fractions, which were estimated by an in vitro digestion method (r2=0.784, p=0.000). These results suggested that the in vitro gastrointestinal model is a more accurate method to evaluate accumulation of and health risks caused by dietary intake of OCPs. This study, which was the first systematic study to investigate concentrations of OCPs in blood of Hong Kong people, provides a baseline to which future measurements can be compared.
KW - Asia
KW - Bioaccumulation
KW - Blood plasma
KW - Dichlorodiphenyltrichloroethane (DDT)
KW - Hexachlorocyclohexane (HCH)
KW - Insecticides
UR - http://www.scopus.com/inward/record.url?scp=84873243223&partnerID=8YFLogxK
U2 - 10.1016/j.envint.2013.01.003
DO - 10.1016/j.envint.2013.01.003
M3 - Journal article
C2 - 23376599
AN - SCOPUS:84873243223
SN - 0160-4120
VL - 54
SP - 18
EP - 25
JO - Environment International
JF - Environment International
ER -
