TY - JOUR
T1 - COMT genotype is differentially associated with single trial variability of ERPs as a function of memory type
AU - Rostami, Hadiseh Nowparast
AU - Saville, Christopher W.N.
AU - Klein, Christoph
AU - Ouyang, Guang
AU - Sommer, Werner
AU - ZHOU, Changsong
AU - Hildebrandt, Andrea
N1 - Funding Information:
This work was partially supported by Hong Kong Baptist University (HKBU) Strategic Development Fund and Hong Kong RGC 12302914, partly supported by a grant from the Deutsche Forschungsgemeinschaft (HI 1780/2-1 & SO 177/26-1) to AH and WS and by a Research Group Linkage Project funded by the Alexander von Humboldt Foundation to CZ, AH, and WS. We are grateful to our anonymous reviewers for their constructive criticism.
PY - 2017/7
Y1 - 2017/7
N2 - Previous research on the association between intra-subject variability (ISV) in reaction times (RTs) and the Val158Met polymorphism of the catechol-o-methyltransferase gene (COMT; rs4680) has yielded mixed results. The present study compared the associations between COMT genotype and ISV in P3b latency measured during working and secondary memory tasks using residue iteration decomposition (RIDE) of single trial latencies. We compared the outcome of the present analyses with a previous analysis of the same data (N = 70, n-back tasks) using an alternative single-trial method. Additionally, we used RIDE to analyse the association between COMT genotype and ISV in an independent sample performing a different task (N = 91, face-recognition task). Analyses reconfirmed previous results from the n-back tasks, showing that Val alleles are associated with lower ISV. In the face recognition tasks, genotype interacted with task conditions, so Val homozygotes had higher ISV to unfamiliar faces than familiar ones but Met carriers showed no effect of familiarity. Moreover, in both datasets trial-by-trial RTs were predicted by P3b latencies. Therefore, the present data suggests that associations between COMT genotype and ISV depend on the type of cognitive processes, which may explain heterogeneity in previous results.
AB - Previous research on the association between intra-subject variability (ISV) in reaction times (RTs) and the Val158Met polymorphism of the catechol-o-methyltransferase gene (COMT; rs4680) has yielded mixed results. The present study compared the associations between COMT genotype and ISV in P3b latency measured during working and secondary memory tasks using residue iteration decomposition (RIDE) of single trial latencies. We compared the outcome of the present analyses with a previous analysis of the same data (N = 70, n-back tasks) using an alternative single-trial method. Additionally, we used RIDE to analyse the association between COMT genotype and ISV in an independent sample performing a different task (N = 91, face-recognition task). Analyses reconfirmed previous results from the n-back tasks, showing that Val alleles are associated with lower ISV. In the face recognition tasks, genotype interacted with task conditions, so Val homozygotes had higher ISV to unfamiliar faces than familiar ones but Met carriers showed no effect of familiarity. Moreover, in both datasets trial-by-trial RTs were predicted by P3b latencies. Therefore, the present data suggests that associations between COMT genotype and ISV depend on the type of cognitive processes, which may explain heterogeneity in previous results.
KW - COMT polymorphism
KW - Event-related potentials
KW - Intra-subject variability
KW - Memory
KW - Single trial analysis
UR - http://www.scopus.com/inward/record.url?scp=85021346731&partnerID=8YFLogxK
U2 - 10.1016/j.biopsycho.2017.06.002
DO - 10.1016/j.biopsycho.2017.06.002
M3 - Journal article
C2 - 28648906
AN - SCOPUS:85021346731
SN - 0301-0511
VL - 127
SP - 209
EP - 219
JO - Biological Psychology
JF - Biological Psychology
ER -