Comprehensive quality evaluation and comparison of Angelica sinensis radix and Angelica acutiloba radix by integrated metabolomics and glycomics

Shan Shan Zhou, Jun XU, Chuen Kam Tsang, Ka Man Yip, Wing Ping Yeung, Zhongzhen ZHAO, Shu Zhu, Hirotoshi Fushimi, Heng Yuan Chang*, Hubiao CHEN

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

Angelica radix (Danggui in Chinese) used in China and Japan is derived from two species of Angelica, namely Angelica sinensis and Angelica acutiloba, respectively. The differences in quality between A. sinensis radix (ASR) and A. acutiloba radix (AAR) should be therefore investigated to guide the medicinal and dietary applications of these two species. Secondary metabolites and carbohydrates have been demonstrated to be the two major kinds of bioactive components of Danggui. However, previously, quality comparison between ASR and AAR intensively concerned secondary metabolites but largely overlooked carbohydrates, thus failing to include or take into consideration an important aspect of the holistic quality of Danggui. In this study, untargeted/targeted metabolomics and glycomics were integrated by multiple chromatography-based analytical techniques for qualitative and quantitative characterization of secondary metabolites and carbohydrates in Danggui so as to comprehensively evaluate and compare the quality of ASR and AAR. The results revealed that not only secondary metabolites but also carbohydrates in ASR and AAR were different in type and amount, which should collectively contribute to their quality difference. By providing more comprehensive chemical information, the research results highlighted the need to assess characteristics of both carbohydrates and secondary metabolites for overall quality evaluation and comparison of ASR and AAR.

Original languageEnglish
Pages (from-to)1122-1137
Number of pages16
JournalJournal of Food and Drug Analysis
Volume26
Issue number3
DOIs
Publication statusPublished - Jul 2018

Scopus Subject Areas

  • Food Science
  • Pharmacology

User-Defined Keywords

  • Angelica acutiloba radix
  • Angelica sinensis radix
  • Glycomics
  • Metabolomics
  • Quality evaluation

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