Complete NMR assignments of the antibacterial biflavonoid GB1 from Garcinia kola

Quan Bin Han; Song Fong Lee; Chun Feng Qiao; Zhen Dan He; Jing Zheng Song; Han Dong Sun; Hong Xi Xu

doi:10.1248/cpb.53.1034

Complete NMR assignments of the antibacterial biflavonoid GB1 from Garcinia kola

Quan Bin Han, Song Fong Lee, Chun Feng Qiao, Zhen Dan He, Jing Zheng Song, Han Dong Sun, Hong Xi Xu^*

^*Corresponding author for this work

Chinese Medicine - Teaching and Research Division

Research output: Contribution to journal › Journal article › peer-review

45 Citations (Scopus)

Abstract

From the antibacterial fraction of the roots of Garcinia kola, 3″,4′,4‴,5,5″,7,7″-heptahydroxy-3, 8″-biflavanone (GB1) was isolated as the major constituent, whose interesting conformations were studied on the basis of its 1D and 2D NMR spectra obtained at different temperatures and in different solvents. GB1 showed antibacterial activities against methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci (VRE) with MIC of 32 and 128 μg/ml, respectively.

Original language	English
Pages (from-to)	1034-1036
Number of pages	3
Journal	Chemical and Pharmaceutical Bulletin
Volume	53
Issue number	8
DOIs	https://doi.org/10.1248/cpb.53.1034
Publication status	Published - Aug 2005

Scopus Subject Areas

Chemistry(all)
Drug Discovery

User-Defined Keywords

Antibacterial
Biflavonoid
Garcinia kola
GB1

Access to Document

10.1248/cpb.53.1034

Cite this

@article{f7b5119431364077b26dd134fca5b394,

title = "Complete NMR assignments of the antibacterial biflavonoid GB1 from Garcinia kola",

abstract = "From the antibacterial fraction of the roots of Garcinia kola, 3″,4′,4‴,5,5″,7,7″-heptahydroxy-3, 8″-biflavanone (GB1) was isolated as the major constituent, whose interesting conformations were studied on the basis of its 1D and 2D NMR spectra obtained at different temperatures and in different solvents. GB1 showed antibacterial activities against methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci (VRE) with MIC of 32 and 128 μg/ml, respectively.",

keywords = "Antibacterial, Biflavonoid, Garcinia kola, GB1",

author = "Han, {Quan Bin} and Lee, {Song Fong} and Qiao, {Chun Feng} and He, {Zhen Dan} and Song, {Jing Zheng} and Sun, {Han Dong} and Xu, {Hong Xi}",

year = "2005",

month = aug,

doi = "10.1248/cpb.53.1034",

language = "English",

volume = "53",

pages = "1034--1036",

journal = "Chemical and Pharmaceutical Bulletin",

issn = "0009-2363",

publisher = "Pharmaceutical Society of Japan",

number = "8",

}

TY - JOUR

T1 - Complete NMR assignments of the antibacterial biflavonoid GB1 from Garcinia kola

AU - Han, Quan Bin

AU - Lee, Song Fong

AU - Qiao, Chun Feng

AU - He, Zhen Dan

AU - Song, Jing Zheng

AU - Sun, Han Dong

AU - Xu, Hong Xi

PY - 2005/8

Y1 - 2005/8

N2 - From the antibacterial fraction of the roots of Garcinia kola, 3″,4′,4‴,5,5″,7,7″-heptahydroxy-3, 8″-biflavanone (GB1) was isolated as the major constituent, whose interesting conformations were studied on the basis of its 1D and 2D NMR spectra obtained at different temperatures and in different solvents. GB1 showed antibacterial activities against methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci (VRE) with MIC of 32 and 128 μg/ml, respectively.

AB - From the antibacterial fraction of the roots of Garcinia kola, 3″,4′,4‴,5,5″,7,7″-heptahydroxy-3, 8″-biflavanone (GB1) was isolated as the major constituent, whose interesting conformations were studied on the basis of its 1D and 2D NMR spectra obtained at different temperatures and in different solvents. GB1 showed antibacterial activities against methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci (VRE) with MIC of 32 and 128 μg/ml, respectively.

KW - Antibacterial

KW - Biflavonoid

KW - Garcinia kola

KW - GB1

UR - http://www.scopus.com/inward/record.url?scp=24944522806&partnerID=8YFLogxK

U2 - 10.1248/cpb.53.1034

DO - 10.1248/cpb.53.1034

M3 - Journal article

SN - 0009-2363

VL - 53

SP - 1034

EP - 1036

JO - Chemical and Pharmaceutical Bulletin

JF - Chemical and Pharmaceutical Bulletin

IS - 8

ER -

Complete NMR assignments of the antibacterial biflavonoid GB1 from Garcinia kola

Abstract

Scopus Subject Areas

User-Defined Keywords

Access to Document

Other files and links

Fingerprint

Cite this