Comparison on gestation and lactation exposure of perfluorinated compounds for newborns

Jiaying Liu, Jingguang Li, Yong Liu, Hing Man Chan, Yunfeng Zhao, Zongwei CAI, Yongning Wu*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

110 Citations (Scopus)

Abstract

Perfluorinated compounds (PFCs) are worldwide present in the environment and the general population. Animal studies have shown developmental toxicity of these compounds. To investigate the PFCs exposure of neonates from mother during gestation and lactation, we analyzed twelve PFCs in matched maternal serum, cord serum and breast milk samples collected from 50 pairs of women and their newborns between June and July 2009 in Jinhu, China. Eight PFCs were detected in serum samples, and five of them were also detectable in breast milk. A significant intercorrelation between PFCs concentrations in matched maternal serum, cord serum and breast milk was observed (p. <. 0.01, r = 0.435-0.911). The median partition ratio was from 0.39:1 (PFDA) to 1.74:1 (PFTrDA) for seven PFCs through the placenta, and was from 0.02:1 (PFOS) to 0.09:1 (PFOA) for five PFCs through the lactation. A high transport efficiency of PFOA both through placental barrier and lactation was observed. The postnatal exposure of PFCs through lactation was higher compared to prenatal exposure, especially for PFOA.

Original languageEnglish
Pages (from-to)1206-1212
Number of pages7
JournalEnvironmental International
Volume37
Issue number7
DOIs
Publication statusPublished - Oct 2011

Scopus Subject Areas

  • Environmental Science(all)

User-Defined Keywords

  • Gestation exposure
  • Lactation exposure
  • Newborns
  • PFCs
  • PFOA
  • PFOS

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