Comparison of the immunoregulatory function of different constituents in radix astragali and radix hedysari

Hubiao CHEN*, Jing Liu, Xuguang Hu, Quan Yang, Zhiling YU, Zhongzhen ZHAO, Tao YI

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

32 Citations (Scopus)
1 Downloads (Pure)

Abstract

Radix Astragali (RA), known as Huangqi in China, is one of the most popular herbal medicines known worldwide to reinforce Qi. RA is traditionally prepared from the dried roots of Astragalus membranaceus (MJHQ) and A. membranaceus var. mongholicus (MGHQ). Radix Hedysari is named Hongqi (HQ), which is similar to RA. We assessed and compared the chemical constituents and bioactivity of RA and HQ. Different constituents were extracted into five major parts and were analyzed using different methods. Comparison of the immunological effects of extracts was done by using two immunological models. Results showed that flavonoids and saponins present in RA and HQ were not only structurally significantly different but also different in their immunological effect. Amino acids extract (AE) in MGHQ shows immunological effect while AE in MJHQ and HQ did not. Polysaccharides comprised the major constituents in RA and HQ. All polysaccharides extract (PE) of the three herbs showed similar levels of immunological effect in both immunological assays.

Original languageEnglish
Article number479426
JournalJournal of Biomedicine and Biotechnology
Volume2010
DOIs
Publication statusPublished - 2010

Scopus Subject Areas

  • Biotechnology
  • Molecular Medicine
  • Molecular Biology
  • Genetics
  • Health, Toxicology and Mutagenesis

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