TY - JOUR
T1 - Comparative quality of the forms of decoction pieces evaluated by multidimensional chemical analysis and chemometrics
T2 - Poria cocos, a pilot study
AU - Zhu, Li Xia
AU - Xu, Jun
AU - Wu, Yun
AU - Su, Li Fei
AU - Ching Lam, Kelly Yin
AU - Qi, Elizabeth R.
AU - Dong, Xiao Ping
AU - Chen, Hubiao
AU - Liu, Yu De
AU - Zhao, Zhongzhen
N1 - Funding Information:
This work was funded by the Research Grants Council, Hong Kong, China (Project No. 12141516) and the National Natural Science Foundation of the People's Republic of China (Project No. 11475248). We acknowledge Mr. Alan Ho from the School of Chinese Medicine, Hong Kong Baptist University, for his technical support in the UHPLC-QTOF-MS/MS and UHPLC-QqQ-MS/MS analysis.
PY - 2019/7
Y1 - 2019/7
N2 - Many Chinese medicinal materials (CMMs) are parts of plants or fungi that have been processed into different physical forms, termed decoction pieces, that are typically boiled in water for consumption. One CMM may have several decoction pieces forms, e.g., slices, small cubes (dice), or grains. The specifications that have different morphological parameters (shape, size and thickness) for these various decoction pieces have been developed over, in some cases, centuries of practice. Nevertheless, whether and how the form of decoction pieces affects the extraction (decoction) dynamics, and quality stability during storage has not been studied. Here, we investigated Poria cocos (PC) as a pilot study; we explore how the form of PC decoction pieces affects its chemistry using multidimensional chemical evaluation such as ultra-performance liquid chromatography-photodiode array-quadrupole time-of-flight mass spectrometry (UHPLC-PDA-QTOF-MS/MS), ultra-performance liquid chromatography-triple quadrupole mass spectrometry (UHPLC-QqQ-MS/MS) and high performance gel permeation chromatography coupled with charged aerosol detector (HPGPC-CAD), combined with analysis of variance (ANOVA), principal component analysis (PCA), factor analysis (FA) and hierarchical cluster analysis (HCA). The results indicated that different specifications had significant differences, and these specifications could be divided into four groups. The comprehensive results of the chemical analyses undertaken here indicate that the highest potentially available quality of PC decoction pieces was in the forms of curl, ultra-small grains and small grains, followed by thin slices. This information not only is conducive to promoting the standardization of the specification/form of PC decoction pieces and maximizing the benefits from its utilization, but also provide a promising strategy for assessing other CMM decoction pieces in different forms.
AB - Many Chinese medicinal materials (CMMs) are parts of plants or fungi that have been processed into different physical forms, termed decoction pieces, that are typically boiled in water for consumption. One CMM may have several decoction pieces forms, e.g., slices, small cubes (dice), or grains. The specifications that have different morphological parameters (shape, size and thickness) for these various decoction pieces have been developed over, in some cases, centuries of practice. Nevertheless, whether and how the form of decoction pieces affects the extraction (decoction) dynamics, and quality stability during storage has not been studied. Here, we investigated Poria cocos (PC) as a pilot study; we explore how the form of PC decoction pieces affects its chemistry using multidimensional chemical evaluation such as ultra-performance liquid chromatography-photodiode array-quadrupole time-of-flight mass spectrometry (UHPLC-PDA-QTOF-MS/MS), ultra-performance liquid chromatography-triple quadrupole mass spectrometry (UHPLC-QqQ-MS/MS) and high performance gel permeation chromatography coupled with charged aerosol detector (HPGPC-CAD), combined with analysis of variance (ANOVA), principal component analysis (PCA), factor analysis (FA) and hierarchical cluster analysis (HCA). The results indicated that different specifications had significant differences, and these specifications could be divided into four groups. The comprehensive results of the chemical analyses undertaken here indicate that the highest potentially available quality of PC decoction pieces was in the forms of curl, ultra-small grains and small grains, followed by thin slices. This information not only is conducive to promoting the standardization of the specification/form of PC decoction pieces and maximizing the benefits from its utilization, but also provide a promising strategy for assessing other CMM decoction pieces in different forms.
KW - Chemometric analyses
KW - Forms
KW - Multidimensional chemical evaluation
KW - Poria cocos decoction pieces
UR - http://www.scopus.com/inward/record.url?scp=85063382917&partnerID=8YFLogxK
U2 - 10.1016/j.jfda.2019.03.002
DO - 10.1016/j.jfda.2019.03.002
M3 - Journal article
AN - SCOPUS:85063382917
SN - 1021-9498
VL - 27
SP - 766
EP - 777
JO - Journal of Food and Drug Analysis
JF - Journal of Food and Drug Analysis
IS - 3
ER -