Comparative efficacy of traditional Chinese herbal injection for chronic renal failure: A systematic review and network meta-analysis of randomized controlled trials

Dongni Shi; Feng Liang; Xihong Wang; Nana Wang; Lin Zhang; Wanting Cui; Jiashuai Deng; Chung Tai Lau; Luofan Zhang; Xuan Zhang

doi:10.1016/j.jtcms.2022.12.004

Comparative efficacy of traditional Chinese herbal injection for chronic renal failure: A systematic review and network meta-analysis of randomized controlled trials

Dongni Shi
, Feng Liang
, Xihong Wang
, Nana Wang
, Lin Zhang
, Wanting Cui
, Jiashuai Deng
, Chung Tai Lau
, Luofan Zhang
, Xuan Zhang^*

^*Corresponding author for this work

Research output: Contribution to journal › Journal article › peer-review

1 Citation (Scopus)

Abstract

Objective: To conduct a systematic review and network meta-analysis (NMA) for the comparison of the efficacy and safety of Chinese herbal injection (CHI) combined with Western medicine (WM) and WM monotherapy for chronic renal failure (CRF).

Methods: Eight databases were searched from inception to August 30, 2022. Randomized controlled trials (RCTs) regarding the comparison of CHI-WM combination therapy and WM monotherapy were included. Literature search, risk-of-bias assessment, and data extraction were conducted by 2 reviewers independently. NMA was performed by Stata 14.0, R 4.0.4 software, and the latest risk of bias assessment tool 2 (RoB 2).

Results: A total of 53 RCTs were finally included, involving 4445 participants and 16 CHIs. RoB 2 showed that 2 of these studies had a high risk of bias. Tianqi injection (TQ) + WM was the most effective in reducing serum creatinine (Scr) level. Xingding injection (XD) + WM was the most effective in reducing blood urea nitrogen (BUN) and cystatin C (Cys C) levels. Guhong injection (GH) + WM had the highest endogenous creatinine clearance rate (Ccr). Shuxuetong injection (SXT) + WM was the most effective in improving the clinical effective rate. Danhong injection (DH) + WM resulted in the lowest 24-h urinary protein quantity (24 h-UPQ), while Danshen injection (DS) + WM led to the lowest blood uric acid (UA) level. Shenfu injection (SF) + WM was the most effective in increasing hemoglobin (Hb) level.

Conclusion: CHIs-WM combination therapy is more effective than WM monotherapy in treating CRF. Considering all of the indicators, SK + WM may be the optimal treatment option for improving renal function in patients with CRF.

Original language	English
Pages (from-to)	83-99
Number of pages	17
Journal	Journal of Traditional Chinese Medical Sciences
Volume	10
Issue number	1
Early online date	13 Dec 2022
DOIs	https://doi.org/10.1016/j.jtcms.2022.12.004
Publication status	Published - Jan 2023

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

User-Defined Keywords

Chinese herbal injections
Chronic renal failure
Combination therapy
Network meta-analysis
Systematic review

Access to Document

10.1016/j.jtcms.2022.12.004

Cite this

Shi, D., Liang, F., Wang, X., Wang, N., Zhang, L., Cui, W., Deng, J., Lau, C. T., Zhang, L., & Zhang, X. (2023). Comparative efficacy of traditional Chinese herbal injection for chronic renal failure: A systematic review and network meta-analysis of randomized controlled trials. Journal of Traditional Chinese Medical Sciences, 10(1), 83-99. https://doi.org/10.1016/j.jtcms.2022.12.004

@article{c2e72d5e855340ff8c406b7df6e1cac2,

title = "Comparative efficacy of traditional Chinese herbal injection for chronic renal failure: A systematic review and network meta-analysis of randomized controlled trials",

abstract = "Objective: To conduct a systematic review and network meta-analysis (NMA) for the comparison of the efficacy and safety of Chinese herbal injection (CHI) combined with Western medicine (WM) and WM monotherapy for chronic renal failure (CRF).Methods: Eight databases were searched from inception to August 30, 2022. Randomized controlled trials (RCTs) regarding the comparison of CHI-WM combination therapy and WM monotherapy were included. Literature search, risk-of-bias assessment, and data extraction were conducted by 2 reviewers independently. NMA was performed by Stata 14.0, R 4.0.4 software, and the latest risk of bias assessment tool 2 (RoB 2).Results: A total of 53 RCTs were finally included, involving 4445 participants and 16 CHIs. RoB 2 showed that 2 of these studies had a high risk of bias. Tianqi injection (TQ) + WM was the most effective in reducing serum creatinine (Scr) level. Xingding injection (XD) + WM was the most effective in reducing blood urea nitrogen (BUN) and cystatin C (Cys C) levels. Guhong injection (GH) + WM had the highest endogenous creatinine clearance rate (Ccr). Shuxuetong injection (SXT) + WM was the most effective in improving the clinical effective rate. Danhong injection (DH) + WM resulted in the lowest 24-h urinary protein quantity (24 h-UPQ), while Danshen injection (DS) + WM led to the lowest blood uric acid (UA) level. Shenfu injection (SF) + WM was the most effective in increasing hemoglobin (Hb) level.Conclusion: CHIs-WM combination therapy is more effective than WM monotherapy in treating CRF. Considering all of the indicators, SK + WM may be the optimal treatment option for improving renal function in patients with CRF.",

keywords = "Chinese herbal injections, Chronic renal failure, Combination therapy, Network meta-analysis, Systematic review",

author = "Dongni Shi and Feng Liang and Xihong Wang and Nana Wang and Lin Zhang and Wanting Cui and Jiashuai Deng and Lau, \{Chung Tai\} and Luofan Zhang and Xuan Zhang",

note = "Funding Information: This work was supported by the Chinese Medicine Development Fund, Hong Kong, China (20B2/027A), China Center for Evidence Based Traditional Chinese Medicine, CCEBTM (2020YJSZX-5), and National Natural Science Foundation of China (81704198). Publisher Copyright: {\textcopyright} 2022 Beijing University of Chinese Medicine.",

year = "2023",

month = jan,

doi = "10.1016/j.jtcms.2022.12.004",

language = "English",

volume = "10",

pages = "83--99",

journal = "Journal of Traditional Chinese Medical Sciences",

issn = "2095-7548",

publisher = "Elsevier",

number = "1",

}

Shi, D, Liang, F, Wang, X, Wang, N, Zhang, L, Cui, W, Deng, J, Lau, CT, Zhang, L & Zhang, X 2023, 'Comparative efficacy of traditional Chinese herbal injection for chronic renal failure: A systematic review and network meta-analysis of randomized controlled trials', Journal of Traditional Chinese Medical Sciences, vol. 10, no. 1, pp. 83-99. https://doi.org/10.1016/j.jtcms.2022.12.004

Comparative efficacy of traditional Chinese herbal injection for chronic renal failure: A systematic review and network meta-analysis of randomized controlled trials. / Shi, Dongni; Liang, Feng; Wang, Xihong et al.
In: Journal of Traditional Chinese Medical Sciences, Vol. 10, No. 1, 01.2023, p. 83-99.

Research output: Contribution to journal › Journal article › peer-review

TY - JOUR

T1 - Comparative efficacy of traditional Chinese herbal injection for chronic renal failure

T2 - A systematic review and network meta-analysis of randomized controlled trials

AU - Shi, Dongni

AU - Liang, Feng

AU - Wang, Xihong

AU - Wang, Nana

AU - Zhang, Lin

AU - Cui, Wanting

AU - Deng, Jiashuai

AU - Lau, Chung Tai

AU - Zhang, Luofan

AU - Zhang, Xuan

N1 - Funding Information: This work was supported by the Chinese Medicine Development Fund, Hong Kong, China (20B2/027A), China Center for Evidence Based Traditional Chinese Medicine, CCEBTM (2020YJSZX-5), and National Natural Science Foundation of China (81704198). Publisher Copyright: © 2022 Beijing University of Chinese Medicine.

PY - 2023/1

Y1 - 2023/1

N2 - Objective: To conduct a systematic review and network meta-analysis (NMA) for the comparison of the efficacy and safety of Chinese herbal injection (CHI) combined with Western medicine (WM) and WM monotherapy for chronic renal failure (CRF).Methods: Eight databases were searched from inception to August 30, 2022. Randomized controlled trials (RCTs) regarding the comparison of CHI-WM combination therapy and WM monotherapy were included. Literature search, risk-of-bias assessment, and data extraction were conducted by 2 reviewers independently. NMA was performed by Stata 14.0, R 4.0.4 software, and the latest risk of bias assessment tool 2 (RoB 2).Results: A total of 53 RCTs were finally included, involving 4445 participants and 16 CHIs. RoB 2 showed that 2 of these studies had a high risk of bias. Tianqi injection (TQ) + WM was the most effective in reducing serum creatinine (Scr) level. Xingding injection (XD) + WM was the most effective in reducing blood urea nitrogen (BUN) and cystatin C (Cys C) levels. Guhong injection (GH) + WM had the highest endogenous creatinine clearance rate (Ccr). Shuxuetong injection (SXT) + WM was the most effective in improving the clinical effective rate. Danhong injection (DH) + WM resulted in the lowest 24-h urinary protein quantity (24 h-UPQ), while Danshen injection (DS) + WM led to the lowest blood uric acid (UA) level. Shenfu injection (SF) + WM was the most effective in increasing hemoglobin (Hb) level.Conclusion: CHIs-WM combination therapy is more effective than WM monotherapy in treating CRF. Considering all of the indicators, SK + WM may be the optimal treatment option for improving renal function in patients with CRF.

AB - Objective: To conduct a systematic review and network meta-analysis (NMA) for the comparison of the efficacy and safety of Chinese herbal injection (CHI) combined with Western medicine (WM) and WM monotherapy for chronic renal failure (CRF).Methods: Eight databases were searched from inception to August 30, 2022. Randomized controlled trials (RCTs) regarding the comparison of CHI-WM combination therapy and WM monotherapy were included. Literature search, risk-of-bias assessment, and data extraction were conducted by 2 reviewers independently. NMA was performed by Stata 14.0, R 4.0.4 software, and the latest risk of bias assessment tool 2 (RoB 2).Results: A total of 53 RCTs were finally included, involving 4445 participants and 16 CHIs. RoB 2 showed that 2 of these studies had a high risk of bias. Tianqi injection (TQ) + WM was the most effective in reducing serum creatinine (Scr) level. Xingding injection (XD) + WM was the most effective in reducing blood urea nitrogen (BUN) and cystatin C (Cys C) levels. Guhong injection (GH) + WM had the highest endogenous creatinine clearance rate (Ccr). Shuxuetong injection (SXT) + WM was the most effective in improving the clinical effective rate. Danhong injection (DH) + WM resulted in the lowest 24-h urinary protein quantity (24 h-UPQ), while Danshen injection (DS) + WM led to the lowest blood uric acid (UA) level. Shenfu injection (SF) + WM was the most effective in increasing hemoglobin (Hb) level.Conclusion: CHIs-WM combination therapy is more effective than WM monotherapy in treating CRF. Considering all of the indicators, SK + WM may be the optimal treatment option for improving renal function in patients with CRF.

KW - Chinese herbal injections

KW - Chronic renal failure

KW - Combination therapy

KW - Network meta-analysis

KW - Systematic review

UR - https://www.scopus.com/pages/publications/85145186153

U2 - 10.1016/j.jtcms.2022.12.004

DO - 10.1016/j.jtcms.2022.12.004

M3 - Journal article

SN - 2095-7548

VL - 10

SP - 83

EP - 99

JO - Journal of Traditional Chinese Medical Sciences

JF - Journal of Traditional Chinese Medical Sciences

IS - 1

ER -

Comparative efficacy of traditional Chinese herbal injection for chronic renal failure: A systematic review and network meta-analysis of randomized controlled trials

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