TY - JOUR
T1 - Comparative efficacy of traditional Chinese herbal injection for chronic renal failure
T2 - A systematic review and network meta-analysis of randomized controlled trials
AU - Shi, Dongni
AU - Liang, Feng
AU - Wang, Xihong
AU - Wang, Nana
AU - Zhang, Lin
AU - Cui, Wanting
AU - Deng, Jiashuai
AU - Lau, Chung Tai
AU - Zhang, Luofan
AU - Zhang, Xuan
N1 - Funding Information:
This work was supported by the Chinese Medicine Development Fund, Hong Kong, China (20B2/027A), China Center for Evidence Based Traditional Chinese Medicine, CCEBTM (2020YJSZX-5), and National Natural Science Foundation of China (81704198).
Publisher Copyright:
© 2022 Beijing University of Chinese Medicine.
PY - 2023/1
Y1 - 2023/1
N2 - Objective: To conduct a systematic review and network meta-analysis (NMA) for the comparison of the efficacy and safety of Chinese herbal injection (CHI) combined with Western medicine (WM) and WM monotherapy for chronic renal failure (CRF).Methods: Eight databases were searched from inception to August 30, 2022. Randomized controlled trials (RCTs) regarding the comparison of CHI-WM combination therapy and WM monotherapy were included. Literature search, risk-of-bias assessment, and data extraction were conducted by 2 reviewers independently. NMA was performed by Stata 14.0, R 4.0.4 software, and the latest risk of bias assessment tool 2 (RoB 2).Results: A total of 53 RCTs were finally included, involving 4445 participants and 16 CHIs. RoB 2 showed that 2 of these studies had a high risk of bias. Tianqi injection (TQ) + WM was the most effective in reducing serum creatinine (Scr) level. Xingding injection (XD) + WM was the most effective in reducing blood urea nitrogen (BUN) and cystatin C (Cys C) levels. Guhong injection (GH) + WM had the highest endogenous creatinine clearance rate (Ccr). Shuxuetong injection (SXT) + WM was the most effective in improving the clinical effective rate. Danhong injection (DH) + WM resulted in the lowest 24-h urinary protein quantity (24 h-UPQ), while Danshen injection (DS) + WM led to the lowest blood uric acid (UA) level. Shenfu injection (SF) + WM was the most effective in increasing hemoglobin (Hb) level.Conclusion: CHIs-WM combination therapy is more effective than WM monotherapy in treating CRF. Considering all of the indicators, SK + WM may be the optimal treatment option for improving renal function in patients with CRF.
AB - Objective: To conduct a systematic review and network meta-analysis (NMA) for the comparison of the efficacy and safety of Chinese herbal injection (CHI) combined with Western medicine (WM) and WM monotherapy for chronic renal failure (CRF).Methods: Eight databases were searched from inception to August 30, 2022. Randomized controlled trials (RCTs) regarding the comparison of CHI-WM combination therapy and WM monotherapy were included. Literature search, risk-of-bias assessment, and data extraction were conducted by 2 reviewers independently. NMA was performed by Stata 14.0, R 4.0.4 software, and the latest risk of bias assessment tool 2 (RoB 2).Results: A total of 53 RCTs were finally included, involving 4445 participants and 16 CHIs. RoB 2 showed that 2 of these studies had a high risk of bias. Tianqi injection (TQ) + WM was the most effective in reducing serum creatinine (Scr) level. Xingding injection (XD) + WM was the most effective in reducing blood urea nitrogen (BUN) and cystatin C (Cys C) levels. Guhong injection (GH) + WM had the highest endogenous creatinine clearance rate (Ccr). Shuxuetong injection (SXT) + WM was the most effective in improving the clinical effective rate. Danhong injection (DH) + WM resulted in the lowest 24-h urinary protein quantity (24 h-UPQ), while Danshen injection (DS) + WM led to the lowest blood uric acid (UA) level. Shenfu injection (SF) + WM was the most effective in increasing hemoglobin (Hb) level.Conclusion: CHIs-WM combination therapy is more effective than WM monotherapy in treating CRF. Considering all of the indicators, SK + WM may be the optimal treatment option for improving renal function in patients with CRF.
KW - Chinese herbal injections
KW - Chronic renal failure
KW - Combination therapy
KW - Network meta-analysis
KW - Systematic review
UR - http://www.scopus.com/inward/record.url?scp=85145186153&partnerID=8YFLogxK
U2 - 10.1016/j.jtcms.2022.12.004
DO - 10.1016/j.jtcms.2022.12.004
M3 - Journal article
SN - 2095-7548
VL - 10
SP - 83
EP - 99
JO - Journal of Traditional Chinese Medical Sciences
JF - Journal of Traditional Chinese Medical Sciences
IS - 1
ER -
