TY - JOUR
T1 - Comparative chemical analysis of Radix Astragali and Radix Hedysari by HPLC
AU - Liu, Yi
AU - Zhang, Xiaojing
AU - Zhao, Yuying
AU - CHEN, Hubiao
AU - Wang, Bin
AU - Zhang, Qingying
N1 - Funding Information:
This project was supported by National Natural Science Foundation of China (20432030 and 20872006) and Quality Standard Project of State Pharmacopoeia Commission of China (YZ-029).
PY - 2012/10/1
Y1 - 2012/10/1
N2 - Radix Astragali and Radix Hedysari, two famous traditional Chinese medicines (TCM), were considered to possess the same efficacy in TCM traditionally. However, modern pharmacological and phytochemical investigations showed that they were different in efficacy and chemical constituents to some degree. In this study, the principal constituents of the two drugs, isoflavonoids and saponins, were comparatively analysed using HPLC-UV and HPLC-ELSD methods. The results showed that there were some common compounds, especially flavonoids, in both drugs, while the differences in the types and contents of their chemical constituents, especially in saponins, were also obvious. The similarities and differences of the chemicals may be responsible, at least partially, for the similarities and differences in their efficacies or bioactivities.
AB - Radix Astragali and Radix Hedysari, two famous traditional Chinese medicines (TCM), were considered to possess the same efficacy in TCM traditionally. However, modern pharmacological and phytochemical investigations showed that they were different in efficacy and chemical constituents to some degree. In this study, the principal constituents of the two drugs, isoflavonoids and saponins, were comparatively analysed using HPLC-UV and HPLC-ELSD methods. The results showed that there were some common compounds, especially flavonoids, in both drugs, while the differences in the types and contents of their chemical constituents, especially in saponins, were also obvious. The similarities and differences of the chemicals may be responsible, at least partially, for the similarities and differences in their efficacies or bioactivities.
KW - Astragalus membranaceus
KW - Astragalus membranaceus var. mongholicus
KW - Hedysarum polybotrys
KW - HPLC
KW - Radix Astragali
KW - Radix Hedysari
UR - http://www.scopus.com/inward/record.url?scp=84867057165&partnerID=8YFLogxK
U2 - 10.1080/14786419.2011.619188
DO - 10.1080/14786419.2011.619188
M3 - Journal article
C2 - 22010833
AN - SCOPUS:84867057165
SN - 1478-6419
VL - 26
SP - 1935
EP - 1938
JO - Natural Product Research
JF - Natural Product Research
IS - 20
ER -