Comparative chemical analysis of Radix Astragali and Radix Hedysari by HPLC

Yi Liu, Xiaojing Zhang, Yuying Zhao, Hubiao CHEN, Bin Wang, Qingying Zhang*

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

15 Citations (Scopus)


Radix Astragali and Radix Hedysari, two famous traditional Chinese medicines (TCM), were considered to possess the same efficacy in TCM traditionally. However, modern pharmacological and phytochemical investigations showed that they were different in efficacy and chemical constituents to some degree. In this study, the principal constituents of the two drugs, isoflavonoids and saponins, were comparatively analysed using HPLC-UV and HPLC-ELSD methods. The results showed that there were some common compounds, especially flavonoids, in both drugs, while the differences in the types and contents of their chemical constituents, especially in saponins, were also obvious. The similarities and differences of the chemicals may be responsible, at least partially, for the similarities and differences in their efficacies or bioactivities.

Original languageEnglish
Pages (from-to)1935-1938
Number of pages4
JournalNatural Product Research
Issue number20
Publication statusPublished - 1 Oct 2012

Scopus Subject Areas

  • Analytical Chemistry
  • Biochemistry
  • Plant Science
  • Organic Chemistry

User-Defined Keywords

  • Astragalus membranaceus
  • Astragalus membranaceus var. mongholicus
  • Hedysarum polybotrys
  • HPLC
  • Radix Astragali
  • Radix Hedysari


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