Combination therapeutics in complex diseases

Bing He, Cheng Lu, Guang Zheng, Xiaojuan He, Maolin Wang, Gao Chen, Ge ZHANG*, Aiping LYU

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

34 Citations (Scopus)

Abstract

The biological redundancies in molecular networks of complex diseases limit the efficacy of many single drug therapies. Combination therapeutics, as a common therapeutic method, involve pharmacological intervention using several drugs that interact with multiple targets in the molecular networks of diseases and may achieve better efficacy and/or less toxicity than monotherapy in practice. The development of combination therapeutics is complicated by several critical issues, including identifying multiple targets, targeting strategies and the drug combination. This review summarizes the current achievements in combination therapeutics, with a particular emphasis on the efforts to develop combination therapeutics for complex diseases.

Original languageEnglish
Pages (from-to)2231-2240
Number of pages10
JournalJournal of Cellular and Molecular Medicine
Volume20
Issue number12
DOIs
Publication statusPublished - 1 Dec 2016

Scopus Subject Areas

  • Molecular Medicine
  • Cell Biology

User-Defined Keywords

  • combination therapeutics
  • complex diseases
  • molecular network

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