Cohort profile: the Diet and Healthy Aging (DaHA) study in Singapore

Rongjun YU, Ye Sun, Kaisy Xinhong Ye, Qiushi Feng, Su Lin Lim, Rathi Mahendran, Irwin Kee Mun Cheah, Roger Sik Yin Foo, Ru Yuan Chua, Xinyi Gwee, Marie Loh, Rani Sarmugam, Wei Wei Thwe Khine, Yin Xia Chao, Anis Larbi, Yuan Kun Lee, Alan Prem Kumar, Brian K. Kennedy, Ee Heok Kua, Lei Feng*

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

6 Citations (Scopus)


How diet is related with cognition and health has not been systematically examined in Asians whose eating habits are very different from their counterparts in the West and the biological mechanisms underlying such links are not well known yet. The diet and healthy aging (DaHA) study is a community-based longitudinal study conducted to examine the role of diet and nutrition in promoting cognitive, emotional, and physical health among community-living elderly Singaporeans. The first wave of DaHA, conducted from 2011 to 2017, provided detailed information on diet and baseline cognitive function and health from 1010 community-living elderly in Singapore. Biomarkers of oxidative stress, systemic inflammation, and genetic information were collected. The ongoing second wave of DaHA is conducted from 2017 to 2020, which provides follow- up assessments using established cognitive tests and clinical tools. This well-characterized cohort, with its archived biological samples and high-quality data on diet and lifestyle factors will allow researchers to explore the relationships among diet, nutrition, genes, cognition, mental and physical health in an extremely cost-effective manner. Translations of the research findings into clinical and public health practices will potentially help to promote cognitive health at the population level and reduce healthcare costs related to cognitive impairment.

Original languageEnglish
Pages (from-to)23889-23899
Number of pages11
Issue number23
Early online date18 Nov 2020
Publication statusPublished - 15 Dec 2020

Scopus Subject Areas

  • Ageing
  • Cell Biology

User-Defined Keywords

  • cognitive impairment
  • cohort profile
  • DaHA
  • diet
  • healthy ageing


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