@article{ce257c6cfaba4c5ba5646ca2359dcb74,
title = "Cognitive improvement and synaptic deficit attenuation by a multifunctional carbazole-based cyanine in AD mice model through regulation of Ca2+/CaMKII/CREB signaling pathway",
abstract = "Accumulation of β-amyloid (Aβ) peptide and hyperphosphorylated tau in the brain is one of the pathological characteristics of Alzheimer's disease (AD) and attractive therapeutic targets in its treatment. In the present study, the cognitive ability of 4-month-old 3 × Tg-AD mice significantly improved after 40 days treatment with intraperitoneal injection of 2.25 mg/kg of SLOH, which is a multifunctional carbazole-based cyanine fluorophore. It reduced Aβ deposition, tau levels and its hyperphosphorylation by modulating AKT and promoting protein phosphatase 2A activity in the brain as well as in the primary neurons of 3 × Tg-AD mice. Moreover, SLOH attenuated synaptic deficit both in vitro and in vivo by regulating the Ca2+/CaMKII/CREB signaling pathway. These findings strongly suggest that SLOH owns a high therapeutic potential to treat early onset AD.",
keywords = "Alzheimer's disease, Aβ, Calcium pathway, Hyperphosphorylated tau, SLOH",
author = "Chen Chen and Di Xu and Zhang, {Zhong Hao} and Jia, {Shi Zheng} and Cao, {Xian Chun} and Chen, {Yu Bin} and Song, {Guo Li} and WONG, {Ricky M S} and Li, {Hung Wing}",
note = "Funding Information: This work was supported by Guangdong Natural Science Foundation (Nos. 2018B030336001, 2018A030310447), and Collaborative Research Fund of Hong Kong Research Grant Council (C2012-15G) and the National Natural Sciences Foundation of China (Nos. 21675135, 31800681). We are extremely thankful to Instrumental Analysis Center of Shenzhen University for excellent technical assistance. Funding Information: This work was supported by Guangdong Natural Science Foundation (Nos. 2018B030336001 , 2018A030310447 ), and Collaborative Research Fund of Hong Kong Research Grant Council ( C2012-15G ) and the National Natural Sciences Foundation of China (Nos. 21675135 , 31800681 ). We are extremely thankful to Instrumental Analysis Center of Shenzhen University for excellent technical assistance.",
year = "2020",
month = may,
doi = "10.1016/j.expneurol.2020.113210",
language = "English",
volume = "327",
journal = "Experimental Neurology",
issn = "0014-4886",
publisher = "Academic Press Inc.",
}