Cobalt(II)-catalyzed asymmetric hydrosilylation of simple ketones using dipyridylphosphine ligands in air

Feng Yu; Xi Chang Zhang; Fei Fei Wu; Ji Ning Zhou; Wenjun Fang; Jing Wu; Albert S.C. Chan

doi:10.1039/c1ob05494e

Cobalt(II)-catalyzed asymmetric hydrosilylation of simple ketones using dipyridylphosphine ligands in air

Feng Yu
, Xi Chang Zhang
, Fei Fei Wu
, Ji Ning Zhou
, Wenjun Fang
, Jing Wu^*
, Albert S.C. Chan

^*Corresponding author for this work

Research output: Contribution to journal › Journal article › peer-review

51 Citations (Scopus)

Abstract

In the presence of PhSiH ₃ as the hydride donor, catalytic amounts of non-racemic dipyridylphosphine and an easy-to-handle cobalt salt Co(OAc) ₂·4H ₂O formed in situ an effective catalyst system for the asymmetric reduction of a diverse range of aryl alkyl ketones with moderate-to-excellent enantioselectivities (up to 96% ee). This approach tolerated the handling of both catalyst and reactants under air without special precautions.

Original language	English
Pages (from-to)	5652-5654
Number of pages	3
Journal	Organic and Biomolecular Chemistry
Volume	9
Issue number	16
Early online date	14 Jun 2011
DOIs	https://doi.org/10.1039/c1ob05494e
Publication status	Published - 21 Aug 2011

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10.1039/c1ob05494e

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title = "Cobalt(II)-catalyzed asymmetric hydrosilylation of simple ketones using dipyridylphosphine ligands in air",

abstract = "In the presence of PhSiH 3 as the hydride donor, catalytic amounts of non-racemic dipyridylphosphine and an easy-to-handle cobalt salt Co(OAc) 2·4H 2O formed in situ an effective catalyst system for the asymmetric reduction of a diverse range of aryl alkyl ketones with moderate-to-excellent enantioselectivities (up to 96\% ee). This approach tolerated the handling of both catalyst and reactants under air without special precautions.",

author = "Feng Yu and Zhang, \{Xi Chang\} and Wu, \{Fei Fei\} and Zhou, \{Ji Ning\} and Wenjun Fang and Jing Wu and Chan, \{Albert S.C.\}",

note = "We thank the National Natural Science Foundation of China (21032003, 20672026), the New Century Excellent Talents in Chinese University Program awarded to Jing Wu (NCET-07-0250), and the Natural Science Foundation of Zhejiang Province (R406378) for financial support of this study. Publisher copyright: {\textcopyright} The Royal Society of Chemistry 2011",

year = "2011",

month = aug,

day = "21",

doi = "10.1039/c1ob05494e",

language = "English",

volume = "9",

pages = "5652--5654",

journal = "Organic and Biomolecular Chemistry",

issn = "1477-0520",

publisher = "Royal Society of Chemistry",

number = "16",

}

TY - JOUR

T1 - Cobalt(II)-catalyzed asymmetric hydrosilylation of simple ketones using dipyridylphosphine ligands in air

AU - Yu, Feng

AU - Zhang, Xi Chang

AU - Wu, Fei Fei

AU - Zhou, Ji Ning

AU - Fang, Wenjun

AU - Wu, Jing

AU - Chan, Albert S.C.

N1 - We thank the National Natural Science Foundation of China (21032003, 20672026), the New Century Excellent Talents in Chinese University Program awarded to Jing Wu (NCET-07-0250), and the Natural Science Foundation of Zhejiang Province (R406378) for financial support of this study. Publisher copyright: © The Royal Society of Chemistry 2011

PY - 2011/8/21

Y1 - 2011/8/21

N2 - In the presence of PhSiH 3 as the hydride donor, catalytic amounts of non-racemic dipyridylphosphine and an easy-to-handle cobalt salt Co(OAc) 2·4H 2O formed in situ an effective catalyst system for the asymmetric reduction of a diverse range of aryl alkyl ketones with moderate-to-excellent enantioselectivities (up to 96% ee). This approach tolerated the handling of both catalyst and reactants under air without special precautions.

AB - In the presence of PhSiH 3 as the hydride donor, catalytic amounts of non-racemic dipyridylphosphine and an easy-to-handle cobalt salt Co(OAc) 2·4H 2O formed in situ an effective catalyst system for the asymmetric reduction of a diverse range of aryl alkyl ketones with moderate-to-excellent enantioselectivities (up to 96% ee). This approach tolerated the handling of both catalyst and reactants under air without special precautions.

UR - https://www.scopus.com/pages/publications/79960984210

U2 - 10.1039/c1ob05494e

DO - 10.1039/c1ob05494e

M3 - Journal article

C2 - 21709901

AN - SCOPUS:79960984210

SN - 1477-0520

VL - 9

SP - 5652

EP - 5654

JO - Organic and Biomolecular Chemistry

JF - Organic and Biomolecular Chemistry

IS - 16

ER -

Cobalt(II)-catalyzed asymmetric hydrosilylation of simple ketones using dipyridylphosphine ligands in air

Abstract

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