Clustering of the group III metabotropic glutamate receptor 4a at parallel fiber synaptic terminals in the rat cerebellar molecular layer

José María Mateos, Izaskun Elezgarai, Rocío Benítez, Alexandra Osorio, Aurora Bilbao, Jon Jatsu Azkue, Rainer Kuhn, Thomas Knöpfel, Pedro Grandes*

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

31 Citations (Scopus)

Abstract

We report in this study with a pre-embedding immunogold method, the clustering of the group III metabotropic glutamate receptor 4a (mGluR4a) along the presynaptic membrane of parallel fiber synaptic terminals in the cerebellar molecular layer. The mGluR4a clusters were homogeneously distributed and interspaced by about 60 nm. These results suggest a particular arrangement of mGluR4a which might help to a rapid and effective activation of this receptor by glutamate.

Original languageEnglish
Pages (from-to)71-74
Number of pages4
JournalNeuroscience Research
Volume35
Issue number1
DOIs
Publication statusPublished - Oct 1999

User-Defined Keywords

  • Cerebellum
  • Electron microscopy
  • Excitatory neurotransmission
  • G-proteins
  • Immunogold
  • Pre- embedding immunocytochemistry

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