Citrus reticulatae pericarpium Extract Decreases the Susceptibility to HFD-Induced Glycolipid Metabolism Disorder in Mice Exposed to Azithromycin in Early Life

Hanqi Lu, Yanting You, Xinghong Zhou, Qiuxing He, Ming Wang, Liqian Chen, Lin Zhou, Xiaomin Sun, Yanyan Liu, Pingping Jiang, Jiaojiao Dai, Xiuqiong Fu, Hiu Yee Kwan, Xiaoshan Zhao*, Linjie Lou*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Studies have shown that gut microbe disorder in mice due to early-life antibiotic exposure promotes glycolipid metabolism disorder in adulthood. However, the underlying mechanism remains unclear and there is not yet an effective intervention or treatment for this process.
Purpose: The study investigated whether early-life azithromycin (AZT) exposure in mice could promote high-fat diet (HFD)-induced glycolipid metabolism disorder in adulthood. Moreover, the effect of citrus reticulata pericarpium (CRP) extract on glycolipid metabolism disorder via regulation of gut microbiome in mice exposed to antibodies early in life were investigated.
Methods and results: Three-week-old mice were treated with AZT (50 mg/kg/day) via drinking water for two weeks and then were fed a CRP diet (1% CRP extract) for four weeks and an HFD for five weeks. The results showed that early-life AZT exposure promoted HFD-induced glycolipid metabolism disorder, increased the levels of inflammatory factors, promoted the flora metabolism product trimethylamine N-oxide (TMAO), and induced microbial disorder in adult mice. Importantly, CRP extract mitigated these effects.
Conclusion: Taken together, these findings suggest that early-life AZT exposure increases the susceptibility to HFD-induced glycolipid metabolism disorder in adult mice, and CRP extract can decrease this susceptibility by regulating gut microbiome.
Original languageEnglish
Article number774433
Number of pages15
JournalFrontiers in Immunology
Volume12
DOIs
Publication statusPublished - 19 Nov 2021

Scopus Subject Areas

  • Immunology and Allergy
  • Immunology

User-Defined Keywords

  • antibiotic exposure
  • Citrus reticulata pericarpium extract
  • early life
  • glycolipid metabolism disorder
  • TMAO

Fingerprint

Dive into the research topics of 'Citrus reticulatae pericarpium Extract Decreases the Susceptibility to HFD-Induced Glycolipid Metabolism Disorder in Mice Exposed to Azithromycin in Early Life'. Together they form a unique fingerprint.

Cite this