Circulating biomarkers for esophageal squamous cell carcinoma

Kenneth K. Lai; Kin Tak Chan; Sarwat Fatima; Nikki P. Lee; Simon Law

doi:10.1007/978-1-62703-456-2_6

Circulating biomarkers for esophageal squamous cell carcinoma

Kenneth K. Lai, Kin Tak Chan, Sarwat Fatima, Nikki P. Lee, Simon Law^*

^*Corresponding author for this work

Chinese Medicine - Clinical Division

Research output: Chapter in book/report/conference proceeding › Chapter › peer-review

1 Citation (Scopus)

Abstract

Esophageal cancer is the eighth most common cancer worldwide and esophageal squamous cell carcinoma (ESCC) is the predominant type in Asia. Surgical resection of the tumor is the mainstay treatment for ESCC. Recent advances in neoadjuvant or adjuvant chemotherapy/chemoradiotherapy for treatment of ESCC have significantly improved prognosis. Despite these advancements, survival of some patients still remains poor in particular for those diagnosed at a late stage. In view of the asymptomatic nature of early ESCC and the limitations of currently used diagnostic methods, there is a pressing need to identify circulatory biomarkers to allow noninvasive and early detection of ESCC. In this chapter, we summarize circulating cancer biomarkers including circulatory proteins, microRNAs, and tumor cells that are found to have elevated level in serum and plasma of ESCC patients when compared to healthy subjects. These biomarkers could help improve the diagnostic efficiency of ESCC.

Original language	English
Title of host publication	New Advances on Disease Biomarkers and Molecular Targets in Biomedicine
Publisher	Humana Press Inc.
Pages	85-103
Number of pages	19
ISBN (Electronic)	9781627034562
ISBN (Print)	1627034552, 9781627034555
DOIs	https://doi.org/10.1007/978-1-62703-456-2_6
Publication status	Published - 1 Nov 2013

User-Defined Keywords

Biomarkers
Esophageal squamous cell carcinoma

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10.1007/978-1-62703-456-2_6

Cite this

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Circulating biomarkers for esophageal squamous cell carcinoma

Abstract

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UN SDGs

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