Cholic-acid-based fluorescent sensor for dicarboxylates and acidic amino acids in aqueous solutions

Shun Ying Liu; Lei Fang; Yong Bing He; Wing Hong Chan; Kai Tai Yeung; Yuen Kit Cheng; Rong Hua Yang

doi:10.1021/ol052341t

Cholic-acid-based fluorescent sensor for dicarboxylates and acidic amino acids in aqueous solutions

Shun Ying Liu, Lei Fang, Yong Bing He, Wing Hong Chan^*, Kai Tai Yeung, Yuen Kit Cheng, Rong Hua Yang

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Journal article › peer-review

131 Citations (Scopus)

Abstract

(Figure Presented) The binding affinities of a cholic-acid-based fluorescent neutral receptor toward dicarboxylate anions and amino acids have been investigated in a CH₃OH/H₂O system (1:1, 0.01 M HEPES buffer, pH = 7.4) by fluorescence titration experiments. The synthetic host bearing four convergent functionalities strongly binds glutamate via multiple hydrogen bonds with a binding constant of (5.57 ± 0.88) × 10 ⁶.

Original language	English
Pages (from-to)	5825-5828
Number of pages	4
Journal	Organic Letters
Volume	7
Issue number	26
DOIs	https://doi.org/10.1021/ol052341t
Publication status	Published - 22 Dec 2005

Scopus Subject Areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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@article{b42fdab1d8cf41cfb2f55cc1dc3a5b8c,

title = "Cholic-acid-based fluorescent sensor for dicarboxylates and acidic amino acids in aqueous solutions",

abstract = "(Figure Presented) The binding affinities of a cholic-acid-based fluorescent neutral receptor toward dicarboxylate anions and amino acids have been investigated in a CH3OH/H2O system (1:1, 0.01 M HEPES buffer, pH = 7.4) by fluorescence titration experiments. The synthetic host bearing four convergent functionalities strongly binds glutamate via multiple hydrogen bonds with a binding constant of (5.57 ± 0.88) × 10 6.",

author = "Liu, {Shun Ying} and Lei Fang and He, {Yong Bing} and Chan, {Wing Hong} and Yeung, {Kai Tai} and Cheng, {Yuen Kit} and Yang, {Rong Hua}",

note = "The financial support of this work by grants from the University Grants Committee of the Hong Kong Special Administrative Region, China (AoE/P-10/01), and from the Hong Kong Baptist University (FRG/04-05/II-18) is acknowledged. ",

year = "2005",

month = dec,

day = "22",

doi = "10.1021/ol052341t",

language = "English",

volume = "7",

pages = "5825--5828",

journal = "Organic Letters",

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publisher = "American Chemical Society",

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TY - JOUR

T1 - Cholic-acid-based fluorescent sensor for dicarboxylates and acidic amino acids in aqueous solutions

AU - Liu, Shun Ying

AU - Fang, Lei

AU - He, Yong Bing

AU - Chan, Wing Hong

AU - Yeung, Kai Tai

AU - Cheng, Yuen Kit

AU - Yang, Rong Hua

N1 - The financial support of this work by grants from the University Grants Committee of the Hong Kong Special Administrative Region, China (AoE/P-10/01), and from the Hong Kong Baptist University (FRG/04-05/II-18) is acknowledged.

PY - 2005/12/22

Y1 - 2005/12/22

N2 - (Figure Presented) The binding affinities of a cholic-acid-based fluorescent neutral receptor toward dicarboxylate anions and amino acids have been investigated in a CH3OH/H2O system (1:1, 0.01 M HEPES buffer, pH = 7.4) by fluorescence titration experiments. The synthetic host bearing four convergent functionalities strongly binds glutamate via multiple hydrogen bonds with a binding constant of (5.57 ± 0.88) × 10 6.

AB - (Figure Presented) The binding affinities of a cholic-acid-based fluorescent neutral receptor toward dicarboxylate anions and amino acids have been investigated in a CH3OH/H2O system (1:1, 0.01 M HEPES buffer, pH = 7.4) by fluorescence titration experiments. The synthetic host bearing four convergent functionalities strongly binds glutamate via multiple hydrogen bonds with a binding constant of (5.57 ± 0.88) × 10 6.

UR - http://www.scopus.com/inward/record.url?scp=30144436966&partnerID=8YFLogxK

U2 - 10.1021/ol052341t

DO - 10.1021/ol052341t

M3 - Journal article

C2 - 16354076

AN - SCOPUS:30144436966

SN - 1523-7060

VL - 7

SP - 5825

EP - 5828

JO - Organic Letters

JF - Organic Letters

IS - 26

ER -

Cholic-acid-based fluorescent sensor for dicarboxylates and acidic amino acids in aqueous solutions

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