@article{3c7abac0d66e49ec8871a8030814da52,
title = "Cholecystokinin release triggered by NMDA receptors produces LTP and sound-sound associative memory",
abstract = "Memory is stored in neural networks via changes in synaptic strength mediated in part by NMDA receptor (NMDAR)-dependent long-term potentiation (LTP). Here we show that a cholecystokinin (CCK)-B receptor (CCKBR) antagonist blocks high-frequency stimulation-induced neocortical LTP, whereas local infusion of CCK induces LTP. CCK-/- mice lacked neocortical LTP and showed deficits in a cue-cue associative learning paradigm; and administration of CCK rescued associative learning deficits. Highfrequency stimulation-induced neocortical LTP was completely blocked by either the NMDAR antagonist or the CCKBR antagonist, while application of either NMDA or CCK induced LTP after lowfrequency stimulation. In the presence of CCK, LTP was still induced even after blockade of NMDARs. Local application of NMDA induced the release of CCK in the neocortex. These findings suggest that NMDARs control the release of CCK, which enables neocortical LTP and the formation of cue-cue associative memory.",
keywords = "Cholecystokinin, Entorhinal cortex, Long-term potentiation, Memory, NMDA receptor",
author = "Xi Chen and Xiao Li and Wong, \{Yin Ting\} and Xuejiao Zheng and Haitao Wang and Yujie Peng and Hemin Feng and Jingyu Feng and Baibado, \{Joewel T.\} and Robert Jesky and Zhedi Wang and Hui Xie and Wenjian Sun and Zicong Zhang and Xu Zhang and Ling He and Nan Zhang and Zhijian Zhang and Peng Tang and Junfeng Su and Hu, \{Ling Li\} and Qing Liu and Xiaobin He and Ailian Tan and Xia Sun and Min Li and Kelvin Wong and Xiaoyu Wang and Cheung, \{Hon Yeung\} and Shum, \{Daisy Kwok Yan\} and Yung, \{Kin Lam\} and Chan, \{Ying Shing\} and Micky Tortorella and Yiping Guo and Fuqiang Xu and Jufang He",
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We thank Guoping Feng (Massachusetts Institute of Technology) and Minmin Luo (Chinese Institute for Brain Research, Beijing) for sharing of some transgenic mouse lines for our preliminary study; Eduardo Lau for administrative and technical assistance; Tomas H{\"o}kfelt (Karolinska Institutet), Richard Salvi (New York University at Buffalo), Kuanhong Wang (NIH), Robert Oswald (Cornell University), Bin Hu (University of Calgary), and Jun Xia (Hong Kong University of Science and Technology) for critical comments; and Colin Blakemore (University of London), and Longnian Lin (East China Normal University) for insightful discussion. 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We thank Guoping Feng (Massachusetts Institute of Technology) and Minmin Luo (Chinese Institute for Brain Research, Beijing) for sharing of some transgenic mouse lines for our preliminary study; Eduardo Lau for administrative and technical assistance; Tomas H{\"o}kfelt (Karolinska Institutet), Richard Salvi (New York University at Buffalo), Kuanhong Wang (NIH), Robert Oswald (Cornell University), Bin Hu (University of Calgary), and Jun Xia (Hong Kong University of Science and Technology) for critical comments; and Colin Blakemore (University of London), and Longnian Lin (East China Normal University) for insightful discussion. This work was supported by Hong Kong Research Grants Council, Guangdong Science and Technology Foundation, Natural Science Foundation of China, and Health and Medical Research Fund, Innovation and Technology Fund (Grants C1014-15G, MRP/ 101/17X, 31571096, 31371114, 31671102, 31200852, 31171060, 03141196, 01121906, 561313M, 11101215M, 11166316M, 11102417M, 11101818M, 2014B050505016). We also thank the following charitable foundations for their generous support: the Charlie Lee Charitable Foundation, the Fong Shu Fook Tong Foundation, and the Croucher Foundation.",
year = "2019",
month = mar,
day = "26",
doi = "10.1073/pnas.1816833116",
language = "English",
volume = "116",
pages = "6397--6406",
journal = "Proceedings of the National Academy of Sciences of the United States of America",
issn = "0027-8424",
publisher = "National Academy of Sciences",
number = "13",
}