TY - JOUR
T1 - Chiral nanoparticle-induced amplification in optical activity of molecules with chiral centers
AU - Yang, Lin
AU - Liu, Junjun
AU - Deng, Junhong
AU - Huang, Zhifeng
N1 - Funding Information:
We gratefully acknowledge Benson Leung (Physics, HKBU) for technical support with TEM, and Winnie Wu (IAM, HKBU) for technical support with XRD and XPS. This work was financially supported by NSFC/91856127, GRF/12200118 and SKLP_1920_P06.
Publisher Copyright:
© 2020 The Authors. InfoMat published by John Wiley & Sons Australia, Ltd on behalf of UESTC.
PY - 2020/11
Y1 - 2020/11
N2 - Sensitive differentiation of an enantiomer from its mirror image (ie, enantiodifferentiation), a perennial challenge for pharmaceutical production and disease diagnosis, is technically limited by the weak optical activity (OA) of enantiomers, mainly due to their dimensional mismatch with light wavelengths in the ultraviolet (UV)-visible region. Here we use silver chiral nanoparticles (Ag CNPs) with nominally sub-5 nm helical pitch (P) to amplify the OA of (2′R, 3′R, 4′S)-riboflavin-5′-phosphate sodium salts (RP), which have been found to indirectly affect metabolic processes, through the formation of an RP thin film (TF) covering a close-packed array of Ag CNPs. The OA of the RP in the deep-UV region can be amplified up to 80-fold, ascribed to the aggregation of RP in the TFs and the interactions between RP and the atomically chiral lattices at the CNPs' surfaces. The former contribution, not associated with the chiral Ag topographies, plays a dominant role by thickening the RP TFs, so that the observed amplification has no enantioselective dependence on the chirality of the Ag CNPs. This study extends progress in the sensitive detection of bio-enantiomers, which is highly desired for advanced bio-detection in disease diagnosis and production of single-enantiomer pharmaceuticals. (Figure presented.)
AB - Sensitive differentiation of an enantiomer from its mirror image (ie, enantiodifferentiation), a perennial challenge for pharmaceutical production and disease diagnosis, is technically limited by the weak optical activity (OA) of enantiomers, mainly due to their dimensional mismatch with light wavelengths in the ultraviolet (UV)-visible region. Here we use silver chiral nanoparticles (Ag CNPs) with nominally sub-5 nm helical pitch (P) to amplify the OA of (2′R, 3′R, 4′S)-riboflavin-5′-phosphate sodium salts (RP), which have been found to indirectly affect metabolic processes, through the formation of an RP thin film (TF) covering a close-packed array of Ag CNPs. The OA of the RP in the deep-UV region can be amplified up to 80-fold, ascribed to the aggregation of RP in the TFs and the interactions between RP and the atomically chiral lattices at the CNPs' surfaces. The former contribution, not associated with the chiral Ag topographies, plays a dominant role by thickening the RP TFs, so that the observed amplification has no enantioselective dependence on the chirality of the Ag CNPs. This study extends progress in the sensitive detection of bio-enantiomers, which is highly desired for advanced bio-detection in disease diagnosis and production of single-enantiomer pharmaceuticals. (Figure presented.)
KW - (2'R,3'R,4'S)-riboflavin-5'-phosphate sodium salt
KW - chiral nanoparticles
KW - circular dichroism
KW - glancing angle deposition
KW - optical activity
UR - http://www.scopus.com/inward/record.url?scp=85122064465&partnerID=8YFLogxK
U2 - 10.1002/inf2.12091
DO - 10.1002/inf2.12091
M3 - Journal article
AN - SCOPUS:85122064465
SN - 2567-3165
VL - 2
SP - 1216
EP - 1224
JO - InfoMat
JF - InfoMat
IS - 6
ER -