Chiral molecularly imprinted polymeric stir bar sorptive extraction for naproxen enantiomer detection in PPCPs

Yujian Liu, Yuanchen Liu, Zhimin Liu*, Xingchen Zhao, Juntong Wei, Hongcheng Liu, Xiaoxi Si, Zhigang Xu*, Zongwei CAI*

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

35 Citations (Scopus)


Chiral micropollutant analysis in pharmaceuticals and personal care products (PPCPs) is interesting but challenging. We firstly developed a series of chiral molecularly imprinted polymeric (CMIP) stir bar sorptive extraction coatings by combining a chiral template with chiral functional monomers via a click reaction for naproxen enantiomer analysis in PPCPs. Heterochiral selectivity was observed in the molecule recognition of the CMIP coatings, which demonstrated good adsorption capability for the chiral template and its structurally similar chiral compounds. The coatings also exhibited excellent enrichment capability for chiral analytes in an aqueous matrix. The surface morphology and pore structure of the CMIP coatings were characterized. The molecular interactions between the chiral template and chiral functional monomer were investigated through UV–vis spectroscopy and theoretical calculations to prove the effective interactions existing in the heterochiral MIPs. The CMIP coatings were used to enrich naproxen enantiomers in chiral drug and environmental water samples, and satisfactory recoveries (83.98 %–118.88 %) with a relative standard deviation of 3.49 %–13.08 % were achieved. The heterochiral imprinted coating-based method provided a sensitive, selective, and effective enrichment strategy for chiral micropollutant analysis in PPCPs. This technique is critical for chiral molecule recognition and enantiomer analysis in complex samples.

Original languageEnglish
Article number122251
JournalJournal of Hazardous Materials
Publication statusPublished - 15 Jun 2020

Scopus Subject Areas

  • Environmental Engineering
  • Environmental Chemistry
  • Waste Management and Disposal
  • Pollution
  • Health, Toxicology and Mutagenesis

User-Defined Keywords

  • Chiral molecularly imprinted polymers
  • Enantiomers
  • Heterochiral selectivity
  • Naproxen
  • Pharmaceuticals and personal care products
  • Stir bar sorptive extraction


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