Abstract
Michael addition of secondary amines 1b-1g onto chiral acetylenic sulfoxides 2 followed by acid induced cyclization afforded structures of tetrahydroisoquinoline skeleton in high to moderate diastereoselectivity. Optical pure (S)-(-)-carnegine has been synthesized.
Original language | English |
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Pages (from-to) | 715-718 |
Number of pages | 4 |
Journal | Tetrahedron Letters |
Volume | 36 |
Issue number | 5 |
DOIs | |
Publication status | Published - 30 Jan 1995 |
Scopus Subject Areas
- Biochemistry
- Drug Discovery
- Organic Chemistry