Chiral acetylenic sulfoxide in enantioselective synthesis of yohimbine alkaloid

Albert W M LEE; Wing Hong CHAN; T. Mo

doi:10.1016/S0040-4039(97)00519-4

Chiral acetylenic sulfoxide in enantioselective synthesis of yohimbine alkaloid

Albert W M LEE^*, Wing Hong CHAN, T. Mo

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

Through Michael addition/acid induced cyclization of secondary amine to chiral acetylenic sulfoxide followed by Pummerer cyclization, an approach to the enantioselective syntheses of pentacyclic yohimbine alkaloids is presented.

Original language	English
Pages (from-to)	3001-3004
Number of pages	4
Journal	Tetrahedron Letters
Volume	38
Issue number	17
DOIs	https://doi.org/10.1016/S0040-4039(97)00519-4
Publication status	Published - 28 Apr 1997

Scopus Subject Areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/S0040-4039(97)00519-4

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title = "Chiral acetylenic sulfoxide in enantioselective synthesis of yohimbine alkaloid",

abstract = "Through Michael addition/acid induced cyclization of secondary amine to chiral acetylenic sulfoxide followed by Pummerer cyclization, an approach to the enantioselective syntheses of pentacyclic yohimbine alkaloids is presented.",

author = "LEE, {Albert W M} and CHAN, {Wing Hong} and T. Mo",

note = "Funding Information: Financial support from the Research Grant Council (HKBC 109/93E) is gratefully acknowledged. ",

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T1 - Chiral acetylenic sulfoxide in enantioselective synthesis of yohimbine alkaloid

AU - LEE, Albert W M

AU - CHAN, Wing Hong

AU - Mo, T.

N1 - Funding Information: Financial support from the Research Grant Council (HKBC 109/93E) is gratefully acknowledged.

PY - 1997/4/28

Y1 - 1997/4/28

N2 - Through Michael addition/acid induced cyclization of secondary amine to chiral acetylenic sulfoxide followed by Pummerer cyclization, an approach to the enantioselective syntheses of pentacyclic yohimbine alkaloids is presented.

AB - Through Michael addition/acid induced cyclization of secondary amine to chiral acetylenic sulfoxide followed by Pummerer cyclization, an approach to the enantioselective syntheses of pentacyclic yohimbine alkaloids is presented.

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U2 - 10.1016/S0040-4039(97)00519-4

DO - 10.1016/S0040-4039(97)00519-4

M3 - Article

AN - SCOPUS:0030890687

SN - 0040-4039

VL - 38

SP - 3001

EP - 3004

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 17

ER -

Chiral acetylenic sulfoxide in enantioselective synthesis of yohimbine alkaloid

Abstract

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