Chiral acetylenic sulfoxide in alkaloid synthesis. Total synthesis of (R)-(+)-carnegine.

Albert W M LEE*, Wing Hong CHAN, Yu Kai Lee

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)

Abstract

Remarkable diastereoselectivity was observed in the cyclization of β-aminovinyl sulfoxide 5a prepared from chiral acetylenic sulfoxide 1a in acidic medium. The cyclized product 6a was then converted to (R)-(+)-carnegine.

Original languageEnglish
Pages (from-to)6861-6864
Number of pages4
JournalTetrahedron Letters
Volume32
Issue number47
DOIs
Publication statusPublished - 18 Nov 1991

Scopus Subject Areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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