TY - JOUR
T1 - Chinese Medicines Induce Cell Death
T2 - The Molecular and Cellular Mechanisms for Cancer Therapy
AU - Wang, Xuanbin
AU - Feng, Yibin
AU - Wang, Ning
AU - Cheung, Fan
AU - Tan, Hor Yue
AU - Zhong, Sen
AU - Li, Charlie
AU - Kobayashi, Seiichi
N1 - Funding information:
The study was financially supported by Grants from the research council of the University of Hong Kong (Project Codes: 10401764 and 104002889), the Open Project of Hubei Key Laboratory of Wudang Local Chinese Medicine Research, Hubei University of Medicine (Grant no. WDCM001), and The Research Grant Committee (RGC) of Hong Kong (RGC General Research Fund, Project Code: 10500362).
Publisher Copyright:
© 2014 Xuanbin Wang et al.
PY - 2014/10/14
Y1 - 2014/10/14
N2 - Chinese medicines have long history in treating cancer. With the growing scientific evidence of biomedical researches and clinical trials in cancer therapy, they are increasingly accepted as a complementary and alternative treatment. One of the mechanisms is to induce cancer cell death. Aim. To comprehensively review the publications concerning cancer cell death induced by Chinese medicines in recent years and provide insights on anticancer drug discovery from Chinese medicines. Materials and Methods. Chinese medicines (including Chinese medicinal herbs, animal parts, and minerals) were used in the study. The key words including "cancer", "cell death", "apoptosis", "autophagy," "necrosis," and "Chinese medicine" were used in retrieval of related information from PubMed and other databases. Results. The cell death induced by Chinese medicines is described as apoptotic, autophagic, or necrotic cell death and other types with an emphasis on their mechanisms of anticancer action. The relationship among different types of cell death induced by Chinese medicines is critically reviewed and discussed. Conclusions. This review summarizes that CMs treatment could induce multiple pathways leading to cancer cell death, in which apoptosis is the dominant type. To apply these preclinical researches to clinic application will be a key issue in the future.
AB - Chinese medicines have long history in treating cancer. With the growing scientific evidence of biomedical researches and clinical trials in cancer therapy, they are increasingly accepted as a complementary and alternative treatment. One of the mechanisms is to induce cancer cell death. Aim. To comprehensively review the publications concerning cancer cell death induced by Chinese medicines in recent years and provide insights on anticancer drug discovery from Chinese medicines. Materials and Methods. Chinese medicines (including Chinese medicinal herbs, animal parts, and minerals) were used in the study. The key words including "cancer", "cell death", "apoptosis", "autophagy," "necrosis," and "Chinese medicine" were used in retrieval of related information from PubMed and other databases. Results. The cell death induced by Chinese medicines is described as apoptotic, autophagic, or necrotic cell death and other types with an emphasis on their mechanisms of anticancer action. The relationship among different types of cell death induced by Chinese medicines is critically reviewed and discussed. Conclusions. This review summarizes that CMs treatment could induce multiple pathways leading to cancer cell death, in which apoptosis is the dominant type. To apply these preclinical researches to clinic application will be a key issue in the future.
UR - http://www.scopus.com/inward/record.url?scp=84908343646&partnerID=8YFLogxK
U2 - 10.1155/2014/530342
DO - 10.1155/2014/530342
M3 - Review article
C2 - 25379508
AN - SCOPUS:84908343646
SN - 2314-6133
VL - 2014
JO - BioMed Research International
JF - BioMed Research International
M1 - 530342
ER -