Chinese medicines in the treatment of experimental diabetic nephropathy

Jing Yi Liu; Xiao Xin Chen; Sydney Chi Wai Tang; Stephen Cho Wing Sze; Yi Bin Feng; Kai Fai Lee; Kalin Yan Bo Zhang

doi:10.1186/s13020-016-0075-z

Chinese medicines in the treatment of experimental diabetic nephropathy

Jing Yi Liu, Xiao Xin Chen, Sydney Chi Wai Tang^*, Stephen Cho Wing Sze, Yi Bin Feng, Kai Fai Lee, Kalin Yan Bo Zhang^*

^*Corresponding author for this work

Golden Meditech Centre for NeuroRegeneration Sciences

Research output: Contribution to journal › Review article › peer-review

8 Citations (Scopus)

Abstract

Diabetic nephropathy (DN) is a severe micro vascular complication accompanying diabetes mellitus that affects millions of people worldwide. End-stage renal disease occurs in nearly half of all DN patients, resulting in large medical costs and lost productivity. The course of DN progression is complicated, and effective and safe therapeutic strategies are desired. While the complex nature of DN renders medicines with a single therapeutic target less efficacious, Chinese medicine, with its holistic view targeting the whole system of the patient, has exhibited efficacy for DN management. This review aims to describe the experimental evidence for Chinese medicines in DN management, with an emphasis on the underlying mechanisms, and to discuss the combined use of herbs and drugs in DN treatment.

Original language	English
Article number	6
Journal	Chinese Medicine
Volume	11
Early online date	24 Feb 2016
DOIs	https://doi.org/10.1186/s13020-016-0075-z
Publication status	Published - Dec 2016

Scopus Subject Areas

Medicine(all)

User-Defined Keywords

Diabetic Nephropathy
Telmisartan
Benazepril
Reactive Oxidative Species
Incipient Stage

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1186/s13020-016-0075-z

Cite this

@article{6923af8a9476440c8e3ad85c8f42db8f,

title = "Chinese medicines in the treatment of experimental diabetic nephropathy",

abstract = "Diabetic nephropathy (DN) is a severe micro vascular complication accompanying diabetes mellitus that affects millions of people worldwide. End-stage renal disease occurs in nearly half of all DN patients, resulting in large medical costs and lost productivity. The course of DN progression is complicated, and effective and safe therapeutic strategies are desired. While the complex nature of DN renders medicines with a single therapeutic target less efficacious, Chinese medicine, with its holistic view targeting the whole system of the patient, has exhibited efficacy for DN management. This review aims to describe the experimental evidence for Chinese medicines in DN management, with an emphasis on the underlying mechanisms, and to discuss the combined use of herbs and drugs in DN treatment.",

keywords = "Diabetic Nephropathy, Telmisartan, Benazepril, Reactive Oxidative Species, Incipient Stage",

author = "Liu, {Jing Yi} and Chen, {Xiao Xin} and Tang, {Sydney Chi Wai} and Sze, {Stephen Cho Wing} and Feng, {Yi Bin} and Lee, {Kai Fai} and Zhang, {Kalin Yan Bo}",

note = "Funding information: This study was supported by grants from Seed Funding Programme for Basic Research from HKU (Project No. 201111159043); the Innovation and Technology Support Programme (Project code: ITS/313/11); and the Government of Hong Kong Special Administrative Region. The funders had no role in the design, analysis or writing of this article. Publisher copyright: {\textcopyright} 2016 Liu et al.",

year = "2016",

month = dec,

doi = "10.1186/s13020-016-0075-z",

language = "English",

volume = "11",

journal = "Chinese Medicine",

issn = "1749-8546",

publisher = "BioMed Central Ltd.",

}

TY - JOUR

T1 - Chinese medicines in the treatment of experimental diabetic nephropathy

AU - Liu, Jing Yi

AU - Chen, Xiao Xin

AU - Tang, Sydney Chi Wai

AU - Sze, Stephen Cho Wing

AU - Feng, Yi Bin

AU - Lee, Kai Fai

AU - Zhang, Kalin Yan Bo

N1 - Funding information: This study was supported by grants from Seed Funding Programme for Basic Research from HKU (Project No. 201111159043); the Innovation and Technology Support Programme (Project code: ITS/313/11); and the Government of Hong Kong Special Administrative Region. The funders had no role in the design, analysis or writing of this article. Publisher copyright: © 2016 Liu et al.

PY - 2016/12

Y1 - 2016/12

N2 - Diabetic nephropathy (DN) is a severe micro vascular complication accompanying diabetes mellitus that affects millions of people worldwide. End-stage renal disease occurs in nearly half of all DN patients, resulting in large medical costs and lost productivity. The course of DN progression is complicated, and effective and safe therapeutic strategies are desired. While the complex nature of DN renders medicines with a single therapeutic target less efficacious, Chinese medicine, with its holistic view targeting the whole system of the patient, has exhibited efficacy for DN management. This review aims to describe the experimental evidence for Chinese medicines in DN management, with an emphasis on the underlying mechanisms, and to discuss the combined use of herbs and drugs in DN treatment.

AB - Diabetic nephropathy (DN) is a severe micro vascular complication accompanying diabetes mellitus that affects millions of people worldwide. End-stage renal disease occurs in nearly half of all DN patients, resulting in large medical costs and lost productivity. The course of DN progression is complicated, and effective and safe therapeutic strategies are desired. While the complex nature of DN renders medicines with a single therapeutic target less efficacious, Chinese medicine, with its holistic view targeting the whole system of the patient, has exhibited efficacy for DN management. This review aims to describe the experimental evidence for Chinese medicines in DN management, with an emphasis on the underlying mechanisms, and to discuss the combined use of herbs and drugs in DN treatment.

KW - Diabetic Nephropathy

KW - Telmisartan

KW - Benazepril

KW - Reactive Oxidative Species

KW - Incipient Stage

UR - http://www.scopus.com/inward/record.url?eid=2-s2.0-84977584879&partnerID=MN8TOARS

U2 - 10.1186/s13020-016-0075-z

DO - 10.1186/s13020-016-0075-z

M3 - Review article

SN - 1749-8546

VL - 11

JO - Chinese Medicine

JF - Chinese Medicine

M1 - 6

ER -

Chinese medicines in the treatment of experimental diabetic nephropathy

Abstract

Scopus Subject Areas

User-Defined Keywords

UN SDGs

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