Chinese medicines in the treatment of experimental diabetic nephropathy

Jing Yi Liu, Xiao Xin Chen, Sydney Chi Wai Tang*, Stephen Cho Wing Sze, Yi Bin Feng, Kai Fai Lee, Kalin Yan Bo Zhang*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

Diabetic nephropathy (DN) is a severe micro vascular complication accompanying diabetes mellitus that affects millions of people worldwide. End-stage renal disease occurs in nearly half of all DN patients, resulting in large medical costs and lost productivity. The course of DN progression is complicated, and effective and safe therapeutic strategies are desired. While the complex nature of DN renders medicines with a single therapeutic target less efficacious, Chinese medicine, with its holistic view targeting the whole system of the patient, has exhibited efficacy for DN management. This review aims to describe the experimental evidence for Chinese medicines in DN management, with an emphasis on the underlying mechanisms, and to discuss the combined use of herbs and drugs in DN treatment.
Original languageEnglish
Article number6
JournalChinese Medicine
Volume11
Early online date24 Feb 2016
DOIs
Publication statusPublished - Dec 2016
Externally publishedYes

Scopus Subject Areas

  • Medicine(all)

User-Defined Keywords

  • Diabetic Nephropathy
  • Telmisartan
  • Benazepril
  • Reactive Oxidative Species
  • Incipient Stage

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